Multiple Inhibitory Effects of a Lutenizing Hormone-Releasing Hormone Agonist on hCG-dependent Steroidogenesis and on FSH-dependent Responses in Ovarian Cells <I>in vivo</I> and <I>in vitro</I>
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概要
- 論文の詳細を見る
[<SUP>125</SUP>I] labelled [D-Leu<SUB>6</SUB>, des-Gly-NH<SUP>10</SUP><SUB>2</SUB>] LH-RH ethylamide (LH-RHa), when injected into immature female rats, bound specifically not only to the pituitary but also to the ovaries. LH-RHa inhibited hCG-stimulated progesterone production and ovarian weight augumentation in hypophysectomized immature female rats <I>in vivo</I>. FSH-induced ovarian hCG receptors and ovarian weight gain in diethylstilbestrol (DES)-treated hypophysectomized immature female rats were also suppressed by LHRHa. Progesterone production by rat luteal cells <I>in vitro</I> was inhibited by LH-RHa. LH-RHa did not change the affinity or population of LH/hCG receptor in porcine granulosa cells in short term incubation. However, LH-RHa inhibited induction of LH/hCG receptor stimulated by FSH and insulin in long term culture of porcine granulosa cells. LH-RHa delayed hCG-stimulated cyclic AMP accumulation in porcine granulosa cells. These findings suggest that LH-RHa inhibits hCG-stimulated cyclic AMP accumulation and subsequent progesterone production as well as FSH-stimulated LH/hCG receptor induction by acting directly on ovarian cells.
- 社団法人 日本内分泌学会の論文
著者
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Maruo Takeshi
Department Of Cardiology Kurashiki Central Hospital
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Maruo Takeshi
Department Of Obstetrics And Gynecology Kobe University School Of Medicine
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Otani Tetsuo
Department Of Obstetrics And Gynecology Kobe University Graduate School Of Medicine
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ASHITAKA Yoshihiko
Department of Gynecology and Obstetrics, Kobe University, Faculty of Medicine
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Tojo Shimpei
Department Of Gynecology And Obstetrics Kyoto University School Of Medicine
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Ashitaka Yoshihiko
Department Of Gynecology And Obstetrics Kobe University Faculty Of Medicine
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TOJO SHIMPEI
Department of Gynecology and Obstetrics Kyoto University Faculty of Medicine
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