Inverse correlation between urinary 17-hydroxycorticosteroid (17-OHCS) excretion and thyrotropin-releasing hormone (TRH)-induced thyrotropin (TSH) response in disorders of adrenocorticotropic hormone (ACTH) and adrenal secretion.
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概要
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A TRH test was performed in patients with Cushing's syndrome and isolated ACTH deficiency, and serum TSH was measured. A TRH-induced TSH showed low response in patients with Cushing's syndrome but showed excessive response in patients with isolated ACTH deficiency. However, in both diseases TRH-induced TSH response showed a tendency to normalize after the treatment.<BR>Urinary 17-OHCS excretion was measured in patients with Cushing's syndrome and isolated ACTH deficiency before and after the treatment. There was a definite inverse correlation between the logarithm for urinary 17-OHCS excretion and the peak TSH response to TRH. These results suggested that glucocorticoids regulate not only ACTH but also TSH secretion.
- 社団法人 日本内分泌学会の論文
著者
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Watanabe Akira
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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WATANABE AKIRA
Department of Internal Medicine, School of Medicine, Kitasato University
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Mashito Takashi
Department of Internal Medicine, School of Medicine, Kitasato University
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TAKADA ICHITARO
Department of Internal Medicine, School of Medicine, Kitasato University
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KENBO TAKASHI
Department of Internal Medicine, School of Medicine, Kitasato University
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