全身オートバクテリオグラフィーによる治療効果の検討 (Oxolinic acidの魚類感染症治療剤としての応用に関する研究-1,2-)

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We have already reported that oxolinic acid (1-ethyl-1, 4-dihydro-6, 7-methylene-dioxy-4-oxo-3-quinolinecarboxylic acid) had a superior antibacterial activity against several bacterial species isolated from various fishes and exhibited chemotherapeutic effects in experimentally infected fishes. In the present study, we administered oxolinic acid to carps infected with A. liquefaciens and to rainbow trouts infected with A. salmonicida, and examined the chemotherapeutic effects of oxolinic acid by whole body autobacteriography. The autobacteriograms of carps infected with A. liquefaciens showed that at various times after administration of oxolinic acid the bacteria were totally absent in the carp tissues. A. salmonicida was also shown to be eradicated from the rainbow trout tissues 24 hours after administration of oxolinic acid. From these results we confirmed that oral administration of oxolinic acid inhibited the growth of infecting bacteria and prevented the expansion of lesions in experimentally infected carps and rainbow trouts.
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