サルファ剤のナトリウム塩をニジマスに経口投与した時の組織内濃度について

概要

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In the previous paper1) it was reported that the rainbow trout did not uptake so much of sulfonamides in a free form into the tissues as the mammals do. Therefore, the experiments in the present report were conducted on the absorption of sulfonamides of water soluble salt by the rainbow trout tissues. The rainbow trout yearling with the average body weight of 78gr. were orally given the free form sulforamides of 250mg per one killogram of body weight in a single dose, and the concentration levels were then measured in plasma, liver, muscle and kidney of the fish by the use of the Bratton and Marshall modificated method. The experimental fiish were kept in the tanks of the water temperature from 9.8 to 15.0°C. As is seen in Tables 1 to 2 and Figs. 1 to 2, the sulfonamides in sodium salts gave the higher concertration level in sulfamonomethoxine and sulfamonomethoxine than the free form sulfonamides did. It is to be noted that even sulfadimethoxine which was hardly absorbed by the fish tissues in the application of a free form of it, raised its concentration in plasma by ca. two times. No difierence in the distribution way in the tissues and also in the acetylated rate was observed between the fish given sulfonamides in the free forms and in the sodium salts.
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