サルファ剤魚体内濃度に関する研究-I : サルファ剤水溶液中での金魚体内への吸収およびその毒性について

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Fxperiments were carried out to examine if gold fish absorbs sulfonamides such as sulfadimethoxine, sulfamonomethoxine and sulfisomidine from their aqueous solutions where the fish is bathed, and also to test their toxicity to the fish. It was found that these drugs were well absorbed by gold fish and their toxicity was low. In the case of sulfadimethoxine, a concentration over 7mg% in the fish body was attained by bathing the fish for 24 hours in 0.1% solution, or for 6 hours in 0.2% or in 0.4% solu-tion. Over 7mg% concentration of sulfamonomethoxine in the fish was reached by bathing in 0.1% solution for 24 hours or 0.2% solution for 6 hours or 0.4% solution for 12 hours. As for sulfisomidine, only 4-5mg % concentration in the fish was obtained by bathing in 0.191, or 0.2% solution for 48 hours, while 7mg% concentration by bathing in 0.35% solution for 24 hours. (Table 5-7, Figs. 1-3). TLms (Median tolerance limit) were calculated to represent the toxicity as shown by bathing. TLms-48 hours were 0.80%, 0.96% and 0.76% for sulfadimethoxine (Table 1, 2), Sul-famonomethoxine (Table 3) and Sulfisomidine (Table 4), respectively.
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