全身オートラジオグラフィーによる放射性化合物の生体内分布に関する研究(第17報) : トリチウム標識2-Methyl-2-n-propylamino-o-propionotoluidide Hydrochloride(^3H-LA-012)の粘膜投与後における分布

概要

論文の詳細を見る
The absorption and distribution of ^3H-labeled local anesthetic, 2-methyl-2-n-propylamino-o-propionotoluidide hydrochloride(^3H-LA-012), were examined by means of wholebody autoradiography of mice after its application to various mucous membranes. When ^3H-LA-012 was administered rectally, the drug was more rapidly absorved, and the highest levels of radioactivity were found in the liver and kidney 10 minutes after the administration. The accumulation of radioactivity was greater after administration to the rectum than to the baccal cavity, vagina, glans penis, and the conjunctival cul-de-sac. At three hours, the level of radioactivity in various organs decreased markedly whereas radioactivity in the gastrointestinal contents increased. The radioactivity was observed slightly in various organs 30 minutes after applying the drug on the glans penis, increased gradually until 3 hours, and disappeared 6 hours after the administration. When ^3H-LA-012 was instilled into the conjunctival cul-de-sac, the drug was found to be systemically distributed through the lacrimal duct, esophagus, and alimintary canel, and that the distribution pattern of the radioactivity was similar to that after administration to the vaccal cavity, vagina, and the glans penis.
公益社団法人日本薬学会の論文
1969-10-25