全身オートラジオグラフィによる放射性化合物の生体内分布に関する研究(第24報) : 3H-Pregnanediolの吸収, 分布および排泄

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Absorption, distribution, and excretion of ^3H-pregnanediol after its percutaneous or intraperitoneal administration in female mice and rats were studied by autoradiography and liquid scintillation counting. Examination of absorption showed that 14% of the percutaneously administered radioactivity was absorbed during 48 hours. Microautoradiograms of rat skin applied with ^3H-pregnanediol ointment suggested that the drug was absorbed through stratum malpighi of the cuticle and hair-follicles. Thirty minutes after intraperitoneal injection of ^3H-pregnanediol in female mice, high concentration of the radioactivity was found in the gall bladder and intestinal content. A moderate level of the radioactivity was observed in the liver. Levels of radioactivity in other tissues were as low as that in blood. The lowest concentration was found in the brain. Twenty-four hours after intraperitoneal administration radioactivity in various organs except in intestinal contents decreased markedly.
1971-01-25