全身オートラジオグラフィーによる放射性化合物の生体内分布に関する研究(第20報) : 腰椎麻酔法における^3H-Quatacaineの猫生体内分布

概要

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Whole body autoradiographic studies were made on the distribution of a radioactive local anesthetics, ^3H-Quatacaine administered intrathecally. Spinal anesthesia was induced in young cats, weighing about 900 g, by injection of 2.5% solution of ^3H-Quatacaine in the spinal canal at the fifth lumbar interspace. Whole body sagittal or transverse sections about 40-60 μ in thickness were prepared with a cold microtome at 5 and 20 min after the administration. It was found that ^3H-Quatacaine and/or its metabolites were distributed in most of the tissues and organs soon after its administration. The highest radioactivity in vein from vena azygos to vena dorsalis demonstrated that the venous drainage might be the main route of departure of ^3H-Quatacaine administered intrathecally. In the spinal canal, considerably high radioactivity was found in the dura water, the periphery of the spinal cord, and dorsal nerve root at subarachnoid space. The concentration of radioactivity was higher in the grey mater, especially at the posterior horn, than in the white mater of the cord. The ganglion cells showed higher accumulation of ^3H-Quatacaine than the nerve fibers of the spinal ganglion.
公益社団法人日本薬学会の論文
1970-06-25