^<14>C-L-DOPAのマウスでの吸収, 分布, 排泄とネコの線状体への取込み

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Absorption, distribution and excretion of ^<14>C-DL-and ^<14>C-L-DOPA in mice were studied by whole-body autoradiography and liquid scintillation counting. The absorption of L-DOPA from the gastrointestinal tract was more rapid than that of DL-DOPA, the half-life being 14 min for the former and 11 min for the latter. The urinary and fecal excretion of the radioactivity was not significantly different between L-and DL-DOPA. Then amount of radioactivity taken up by mouse brain was slightly more for L-DOPA than that DL-DOPA. When the mouse was treated with α-methyldopa, the uptake of ^<14>C-L-DOPA into the brain, especially into caudate nucleus, increased compared to that in untreated animal. The autoradiograms of cat brain 30 min after administration of ^<14>C-L-DOPA showed that the concentration of radioactivity in caudate nucleus and putamen was especially high but that in white matter was low. The time-dependent autoradiograms of mouse that received ^<14>C-L-DOPA indicated a longer lasting accumulation of radioactivity in adrenal medulla. However, when the mouse was kept in a cold bath, the radioactivity accumulated in adrenal medulla decreased markedly.
公益社団法人日本薬学会の論文
1972-05-25