Sialyltransferase is excreted by hepatic carcinoma tissue resulting in high levels in circulating blood.
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It has been shown that the sialyltransferase activity in serum and in plasma from cases of hepatocellular carcinoma and cancer metastatic to the liver is markedly high. This study was made to elucidate the origin of increased sialyltransferase activity in blood by means of a tumorbearing mouse experiment.<BR>In C3H/He mice to which the MH134 cell line of mouse ascites hepatoma had been transplanted, the enzyme activity was high in serum and hepatic tissue but low in cancer tissue. Examining the results of 48-hour culture of Chang liver cells and the MH134 cell line, higher enzyme activity was observed in the culture supernatant of the latter and in the cultured cells of the former.<BR>These findings indicate that sialyltransferase is excreted by carcinoma tissue in cases of cancer of the liver, resulting in high levels in circulating blood.
- 社団法人 日本肝臓学会の論文
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