Effect of Rehabilitation on Bone Metabolism. Change in Markers of Bone Metabolism at Spine, Sitting and Walking Levels in a Patient with Cerebral Hemorrhage.

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The effect of rehabilitation on bone metabolism was examined in a patient with cerebral hemorrhage who recovered and could walk within three months after the initial diagnosis. Along with her recovery, the increased urinary calcium excretion decreased markedly but urinary phosphorus did not change. Urinary pyridinoline and deoxypyridinoline, which are suitable makers of bone resorption, and serum osteocalcin, which is a marker of bone formation, increased until 4 weeks, decreased until 8 weeks, and then increased again. The serum PTH level increased slightly until 10 weeks and then decreased. These findings indicate that bone resorption increased in the supine state but bone formation is facilitated with walking, suggesting that rehabilitation is useful for patients with cerebrovascular disease from the viewpoint of bone metabolism.