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A 33-year-old man was admitted with chief complaints of skin purpura family history and past history were nothing particular. On admission, RBC was 387×104/mm3, WBC 2700/mm3, plateletes 1.6×104/mm3 and nucleated cell counts (NCC) was 5600/mm3. He had also jaundice and hypertransaminasemia. HBsAg, antiHBs and antiIgMHA were all negative. On the basis of clinical course and laboratory data, the diagnosis of hepatitis associated with aplastic anemia was made. Since the usual treatments were not effective, plasma exchange therapy was performed 3 times. After this therapy, jaundice was decreased and blood cell counts were increased gradually. 60 days later, NCC was increased to 6000/mm3, 130 days Iater, 27500/mm3 and 180 days later, 37200/mm3. At present, 1 year and 4 months after the onset, his RBC was 430×104/mm3, WBC 6200/mm3, plateletes9×104/mm3. We emphasized the usefullness of plasma exchange therapy for this type of illness.
社団法人日本肝臓学会の論文