Natural history of HBeAg positive hepatitis B virus carrier infants with a special regard to HBsAg subtype.

概要

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Seroconversion (SC) from HBeAg to anti-HBe and s-GPT in 53 infants with HBeAg positive Hepatitis B Virus (HBV) carriers after either horizontal or vertical infection of HBV was observed for a mean period of 8.6 years. Thirty-five infants were male, 18 were female. The age was 5.0±1.8 (mean± S.D.) years.<BR>The subtype of HBsAg, adr, ayw, adw carriers were 21, 28, 4 infants, respectively. SC was observed in 27 of 53 (51%) infants for 8.6 years (5.9% yearly). In vertical infection infants, SC was occured in 4 out of 8 (50%) infants, the rate of which is same to those of horizontal infection. In either male or female, yearly SC rate were 5.4%, 7.2%, respectively. In the type of adr, ayw, adw carriers, yearly SC rate were 5.1, 6.4, 8.1%, respectively. There was no significant differences among different subtypes. SC was occured yearly in similar rate from 8 years onward. Anti-HBe rate was 78% by 17 year old age.
社団法人日本肝臓学会の論文