The efficacy of ATP and allopurinol(AL) pretreatment against hypothermic ischemia-reperfusion injury of liver.

概要

論文の詳細を見る
The mechanism of ischemia-reperfusion injury of liver and its treatment were studied using an ex-vivo perfusion system with Collins solution alone or Collins plus ATP, AL, superoxide dismutase (SOD) and catalase (CAT). ATP plus AL improved not only glucose production and bile production during perfusion, but also wet/dry weight, Na/K and energy charge of the liver taken after perfusion compared with the liver from the control group perfused with collins solution alone. However other groups did not have any significant improvement compared with control group. The negative results with eigher AL alone or SOD/CAT suggest that oxygen free radical did not play an important role on reperfusion injury after hypothermic ischemia. These data indicate that the mechanism of action of AL with ATP might be not to prevent oxygen free radical generatio, but to preserve purine to be recycled via salvage pathways.
社団法人日本肝臓学会の論文