STUDIES ON THE RESPIRATORY AND SYSTEMIC CELL-MEDIATED IMMUNITY:DEVELOPMENT OF LOCAL AND SYSTEMIC CELL-MEDIATED IMMUNITY IN GUINEA PIGS GIVEN KILLED BCG INTRATRACHEALLY OR PARENTERALLY
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Local cell-mediated immunity (CMI) in the respiratory tract and systemic CMI were evaluated. Cellular immune response was tested by the estimation of delayed skin reactivity to purified protein derivative of M. tuberculosis (PPD) and inhibition of macrophage migration (IMM) at various intervals after the immunization of guinea pigs with heat killed bacillus Calmette Guerin (BCG). As an indicator of local respiratory sensitivity, IMM using bronchial washing cells was adopted, while as an indicator of systemic immune response, IMM with peritoneal exudate cells and skin reactivity to PPD were used.The animals immunized with heat killed BCG via intratracheal route developed significantly greater local CMI than animals immunized via sub cutaneous route, whereas parenterally immunized animals showed greater systemic immunity than intratracheally immunized animals. From the results of delayed skin reaction and IMM with pulmonary or peritoneal cells, skin reactions correlated with IMM by peritoneal exudate cells but not with IMM by respiratory tract cells.CMI was also evaluated by resistance to infection of M. tuberculosis H37Rv challenged via intratracheal or subcutaneous route. Intratracheal immunization induced higher protection against intratracheal challenge than subcutaneous immunization. On the contrary, subcutaneous immunization de veloped higher resistance to subcutaneous infection. Therefore, local and sys temic protection against infection correlated with either local and systemic CMI measured by IMM respectively.
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- STUDIES ON THE RESPIRATORY AND SYSTEMIC CELL-MEDIATED IMMUNITY:DEVELOPMENT OF LOCAL AND SYSTEMIC CELL-MEDIATED IMMUNITY IN GUINEA PIGS GIVEN KILLED BCG INTRATRACHEALLY OR PARENTERALLY
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