The visual input pathway to the cerbellar flocculus.

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In order to identify the origin of the mossy fibers which convey the visual input to the cerebellar flocculus, tracer experiments with the method of retrograde axonal transport of horse-radish peroxidase (HRP) and electrophysiological experiments of plotting the stimulation threshold curve and destroying of the brain stem were performed in cats.<BR>Following careful electrophoretic introduction of HRP into the flocculus, labeled neurons with HRP were detected in (1) the dorsal cap of the contralateral inferior olive to the injection site, (2) the bilateral vestibular nuclei, (3) the bilateral perihypoglossal complex, (4) the ipsilateral lateral reticular nucleus, and (5) the bilateral pontine tegmental reticular nucleus (Bechterew) NRT.<BR>These findings were consistent with those in the previous reports. In the present experiments, however, labeled neurons were found only in the medial part of the NRT, but not in the lateral part such as the processus tegmentosus lateralis. Furthermore, a larger number of labeled neurons was counted in the contralateral NRT compared with the ipsilateral NRT. No labeled neuron could be detected in the pontine nuclei or the accessory optic tract nucleus.<BR>Electrical stimulation (pulse width 0.05msec) of the NRT induced the evoked potentials in the flocculus. The threshold current for the evoked potential was lowest in the NRT (lower than 100μA). After electrolytic destruction of the NRT by the passing of positve DC current (1mA, 20sec), the component attributed to the mossy fiber activation of the visually induced potentials in the flocculus decreased markedly in its amplitude.<BR>These above-mentioned findings suggest strogly that the NRT may project to the flocculus and that this pathway may be at least part of the relay nuclei of the visual input from the retina to the flocculus.
日本めまい平衡医学会の論文

The visual input pathway to the cerbellar flocculus.

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