Immunological and clinical studies on peripheral lymphocyte polarization test in patients with gynecological malignancies and healthy controls.

概要

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We studied clinical and immunological association between various immune parameters and SCM test which measured lymphocyte polarization change induced by the stimulation with phytohemagglutinin (PHA). It was found that number of peripheral lymphocytes, diameter of immune cutaneous tests or concentration of serum complements was identical among cancer patients with SCM-R_??_1 and healthy controls with SCM-R<1. It was also found that blastogenesis was higher in lymphocyte samples with SCM-R<1 as compared with those with SCM-R_??_1. Although blastogenesis and change of polarization are the phenomena expressed at different sites in lymphocyte, it is probable that same lymphocyte subpopulation is responsible for these two different phenomena. Lower percentages of B lymphocyte were noted in cell samples with SCM-R_??_1, and it was suggested that interaction between T lymphocyte and B lymphocyte was necessary for the stimulation of lymphocyte with PHA.Clinically, descrease of SCM-R values was found in cancer patients who received immunotherapy with OK-432 for more than 4 weeks, and short incubation of SCM-R_??_1 lymphocytes in culture fluid containing OK-432 reduced SCM-R values to less than unity. Therefore, it was suggested that direct activation of lymphocyte with OK-432 was clinically responsible for decrease of SCM-R values after immunotherapy.
日本臨床免疫学会の論文