Studies on theophylline sensitive and resistant T cells:Stimulating and responding activities of theophylline sensitive T cells in the mixed lymphocyte reaction

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Human peripheral blood T lymphocytes were separated into theophylline-sensitive T cells (Tsen) and theophylline-resistant T cells (Tres); Tsen cells which lost the capacity to bind sheep red blood cells in the presence of the drug; Tres cells which were unaffected by the drug. Tsen cells could stimulate allogeneic cells in mixed lymphocyte reaction, but could not stimulate autologous unseparated T cells (Ttotal). Tres cells did not have the ability to stimulate al'ogeneic and autologous cells.When we placed Tsen cells and Tres cells as responding cells in autologous mixed lymphocyte culture, both of the responses were significantly lower than that obtained when we placed unseparated T cells. These results suggest that the decreased autologous MLR may reflect an imbalance of Tsen cells and Tres cells.
日本臨床免疫学会の論文