A suppressor inducing factor (s) in sera from patients with esophgeal cancer

概要

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We investigated the factor (s) in sera from patients with esophageal cancer that induced suppressor T cells for antibody production driven by pokeweed mitogen (PWM), one way mixed lymphocyte culture reaction (MLR), natural killer (NK) activity, or killer T cell activity against allogenic lymphoid cell line (Raji), or autologous EB virus transformed lymphoblasts (EBV-TL), using TnonG cells treated with sera from patients.There were no serum which induced suppressor T cells for one way MLR or NK activity, while some sera induced suppressor T cells for antibody production or killer T cell activity against EBV-TL.The activity inducing suppressor T cells for killer T cells against EBV-TL was fonnd in the fraction of MW 43, 000_??_50, 000 by sephadex G 100 gel chromatography.The factor was considered to be different from the factor which induce suppressor T cells for antibody production.
日本臨床免疫学会の論文