Studies of immunological findings on immunoblastic lymphadenopathy
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Immunological findings were evaluated in 2 males and 3 females between the ages of 48 and 59 years in whom a definitive diagnosis of immunoblastic lymphadenopathy (IBL) was made from the histological findings obtained in lymph node biopsies and at autopsy (4 patients).Many of these patients exhibited drug hypersensitivity which could also have prompted the onset of disease. Pruritus, eruptions, and recurrent fever were also experienced. In addition to enlargement of superficial lymph nodes all over the body, mediastinal lymph nodes were also enlarged and hepatosplenomegaly was observed in 4 patients. Complications from infection and autoimmune hemolytic anemia were also found, and infection was in fact responsible for the death of 3 of 4 patients. Various abnormal antibodies also appeared, and the antiglobulin test was positive in 3 of 4 patients tested, showing polyclonal hypergammaglobulinemia. In 1 patient, Fc fragment was found in the urine. Abnormal cell-mediated immunity was also found. The response of peripheral lymphocytes to Con A was decreased. Ig secreting cells markedly increased in response to PWM, suggesting an activation of the antibody-producing system. The serum of the patient showed an inhibition of blast formation in response to the PHA and MLC test. Helper T cell hyperfunction and suppressor T cell hypofunction is apparently present in patients with IBL, suggesting a serum factor that suppresses T cell function.
- 日本臨床免疫学会の論文
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