Systemic lupus erythematosus associated with leukocytoclastic vasculitis: Report of a case treated by methylprednisolone pulse therapy

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A 23-year-old woman with systemic lupus erythematosus (SLE) known since age 15 years developed multiple urticaria-like lesions associated with hypocomplementemia unresponsive to 30 mg/day prednisolone. Following the intravenous infusion of 1 g of methylprednisolone daily for 3 days, skin lesions subsided and hypocomplementemia was promptly corrected. Histopathological examinations of the biopsied specimen of the skin lesion demonstrated leukocytoclastic vasculitis. A review of the literature indicates that leukocytoclastic vasculitis with the clinical picture of urticaria-like lesion may complicate SLE associated with hypocomplementemia. Some of these patients have been reported to develop progressive renal failure, a tendency which needs to be confirmed by further study.
日本臨床免疫学会の論文