Potentiation of the NGF-mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia.
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概要
- 論文の詳細を見る
The fiber outgrowth induced by ACh, dibutvryl cyclic AMP and dibutyryl cyclic GMP in explanted chick embryonic dorsal root ganglia differed distinctly from that by nerve growth factor (NGF) and submandibular gland extract of adult male mice. Ginsenoside Rb<SUB>1</SUB> potentiated the effects of NGF and submandibular extract at concentrations of 3 and 30 μM. but did not potentiate the effects of ACh, dibutyryl cyclic AMP and dibutyryl cyclic GMP. NGF-antihody inhibited the effects of NGF, but not the effects of ACh, dibutyryl cyclic AMP and dibutvryl cyclic GMP. Concanavalin A and KCL did not promote fiber outgrowth.
- 公益社団法人 日本薬理学会の論文
著者
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SUDA Kitaru
Department of Pharmacology, Biocenter of the University
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THOENEN Hans
Department of Pharmacology, Biocenter of the University
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SCHWAB Martin
Department of Pharmacology, Biocenter of the University
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Saito Hiroshi
Department of Applied Chemistry, Graduate School of Engineering, Tohoku University
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