INHIBITION OF CATECHOL-O-METHYLTRANSFERASE BY HYDROXYBENZENES AND RELATED COMPOUNDS
スポンサーリンク
概要
- 論文の詳細を見る
The inhibitory action of 1, 2, 3-trihydroxybenzene (pyrogallol) on the activity of catechol-O-methyltransferase (COMT) is well known (1-4). Recently, 1, 3, 5, -trihydroxy-benezene (phloroglucinol) and 2, 4, 6-trihydroxy-l-propiophenone (THPP) have been shown to exert spasmolytic action in experimental animals and to relieve spastic disorders of the urinary tract and biliary ducts in patients (5-10). Comparing the relative effects of trihydroxybenzenes on the smooth muscle organs, Inoue and associates (11-13) have found that these compounds possess catecholamine-like actions and potentiate the effect of catecholamines. Therefore, it is expected that phloroglucinol and THPP also inhibit the COMT activity. In the present experiments, the effects of phenol, phenolic ethanolamines, dihydroxybenzenes, trihydroxybenzenes and related compounds on the COMT activity of rat liver were studied <I>in vitro</I>.
- 社団法人 日本薬理学会の論文
著者
-
藤原 元始
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
島本 暉朗
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
服部 圭佑
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
松浦 雅子
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- RESPONSE TO SYMPATHETIC NERVE STIMULATION AND NORADRENALINE IN ATRIA TREATED WITH RESERPINE AND IN ATRIA FROM RABBITS PRETREATED WITH RESERPINE
- THE MODE OF HYPOTENSIVE ACTIONS OF 2-(2, 6-DICHLOROPHENYL-L-AMINO)-IMIDAZOLINE IN THE RABBIT
- EFFECTS OF THIAMINE DERIVATIVES ON THE ATRIAL TRANSMEMBRANE POTENTIALS AND SPONTANEOUS CONTRACTION IN THE RABBIT
- EFFECTS OF N, N-DIPHENYLDICARBAMATE-1, 1-DEMETHYLOL CYCLOPENTANE (CAMALON) ON THE SPINAL CORD REFLEXES
- FATTY LIVER CAUSED BY THE REPETITIVE ADMINISTRATION OF RELATIVELY SMALL DOSES OF CARBON TETRACHLORIDE IN RATS
- FLUOROMETRIC ASSAY OF TISSUE HISTAMINE
- PHARMACOLOGICAL ACTION OF OCTOPAMINE WITH SPECIAL REFERENCE TO BIOCHEMICAL CONVERSION TO NORADRENALINE
- EFFECTS OF CENTRAL DEPRESSANTS ON THE EVOKED POTENTIALS IN THE INFERIOR COLLICULUS CAUSED BY ACOUSTIC STIMULI IN THE CAT
- INHIBITION OF THE COMT ACTIVITY BY 1-(3, 4, 5-TRI-METHOXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHY-DROISOQUINOLINE AND 1-(3, 5-DIMETHOXY-4-HYDROXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHYDROISOQUINOLINE IN VITRO
- INHIBITION OF CATECHOL-O-METHYLTRANSFERASE BY HYDROXYBENZENES AND RELATED COMPOUNDS
- THE UPTAKE OF DOPAMINE-14C AND ITS CONVERSION TO NORADRENALINE-14C IN RATS
- THE EFFECTS OF RESERPINE ON THE SPONTANEOUS CONTRACTION OF THE ISOLATED ATRIUM OF RABBIT TREATED WITH MONOAMINE OXIDASE INHIBITORS
- ELECTROENCEPHALOGRAPHIC STUDIES ON THIAMINE DERIVATIVES IN THE RABBIT
- THE CENTRAL ACTION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRATE
- FLUORESCENCE HISTOCHEMICAL FINDINGS OF THE STOMACH WALLS IN RESPONSE TO ULCEROGENIC STIMULI IN RATS
- FLUORESCENCE HISTOCHEMICAL DEMONSTRATION OF ADRENERGIC NERVE FIBERS IN THE VAGUS NERVE OF CATS AND DOGS
- EFFECTS OF DECASERPINE ON THE CONTENT OF CATECHOLAMINE IN THE BRAIN, ATRIUM AND ADRENAL GLAND OF RABBIT
- SPECIES DIFFERENCES OF SERUM AND LIVER CHOLESTEROL LEVELS BETWEEN RABBITS AND RATS FED ON HIGH-CHOLESTEROL DIET
- CENTRAL DEPRESSANTS AND EVOKED CLICK RESPONSES WITH SPECIAL REFERENCE TO THE RETICULAR FORMATION IN THE CAT
- CHRONIC ORAL TOXICITY OF 3, 5, 3'-TRIIODO-4'-ACETYLTHYROFORMIC ACID WITH SPECIAL REFERENCE TO CHOLESTEROLYTIC EFFECTS
- EFFECTS OF ETHYL-LINOLEATE ON THE ATHEROMATOUS CHANGES CAUSED BY HIGH CHOLESTEROL DIET IN THE RABBIT
- HISTOCHEMICAL DEMONSTRATION OF NORADRENALINE IN RAT SALIVARY GLANDS
- COMPARISON OF THE OPTICAL ISOMERS OF XYLOPININE
- EFFECTS OF THE ADRENERGIC DRUGS ON THE CHRONO- AND INOTROPIC RESPONSES TO THE CHOLINERGIC STIMULATION OF THE ISOLATED GUINEA-PIG'S ATRIA
- HISTOCHEMICAL DEMONSTRATION OF MONOAMINES IN THE THYMUS OF RATS
- EFFECTS OF VAGAL STIMULATION ON THE TRANSMEMBRANE ACTION POTENTIALS OF ATRIUM ISOLATED FROM GUINEA PIG
- MODIFICATIONS OF THE VAGAL EFFECT ON THE HEART AND THE CARDIAC METABOLISM BY RESERPINE IN VITRO
- EFFECTS OF TEMPERATURE CHANGE, OXYGEN DEPRIVATION AND CATIONS ON THE ATRIAL RESPONSES TO VAGAL STIMULATION
- EFFECTS OF CARNITINE ON THE SPONTANEOUS CONTRACTION AND THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S ATRIA
- THE EFFECTS OF THE ADRENOLYTICS ON THE CATECHOLAMINE CONTENT OF VARIOUS TISSUES IN RABBIT
- DEVELOPMENTAL ABNORMALITIES OF SKELETAL SYSTEM INDUCED BY ETHYLURETHAN IN THE RAT
- EFFECTS OF 10-METHOXYDESERPIDINE AND RESERPINE ON THE SKIN AND RECTAL TEMPERATURE IN RABBITS
- EFFECTS OF SKF-385 AND RESERPINE ON THE TISSUE CATECHOLAMINE CONTENT IN RABBITS
- DEPLETION OF ATRIAL NOREPINEPHRINE INDUCED BY RESERPINE IN VITRO
- TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS
- EFFECTS OF 10-METHOXYDESERPIDINE ON THE ECG CHANGES INDUCED BY VASOPRESSIN IN UNANESTHETIZED RABBIT
- THE UPTAKE OF NORADRENALINE BY TISSUES AFTER THE CONTINUOUS INFUSION TO RABBIT
- THE EFFECT OF RESERPINE ON PHOSPHORYLASE ACTIVITY IN THE ISOLATED RABBIT ATRIA