TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS
スポンサーリンク
概要
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The presence of octopamine in the secretion of the salivary gland of <I>Octopus vulgaris</I> was first demonstrated by Erspamer (1). Kakimoto and Armstrong (2) showed the occurrence of this amine in various tissues of rabbits treated with monoamine oxidase inhibitors. However, paper chromatographic studies of the tissue level of octopamine did not give precise information about small changes of the amine level. Based upon the reaction that octopamine is converted quantitatively to p-hydroxybenzaldehyde by periodate oxidation in ammonia alkaline medium (3), the amount of tissue and blood octopamine could be evaluated by measuring the ultraviolet absorption of the oxidation product. In the present experiments the distribution of exogenously administered octopamine and the accumulation of endogenous octopamine after a monoamine oxidase inhibitor were studied in the blood, brain stem, heart, submaxillary glands, spleen and stomach of the rat.
- 公益社団法人 日本薬理学会の論文
著者
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藤原 元始
Department of Pharmacology, Faculty of Medicine, Kyoto University
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大隅 清明
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
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- FLUOROMETRIC ASSAY OF TISSUE HISTAMINE
- PHARMACOLOGICAL ACTION OF OCTOPAMINE WITH SPECIAL REFERENCE TO BIOCHEMICAL CONVERSION TO NORADRENALINE
- INHIBITION OF CATECHOL-O-METHYLTRANSFERASE BY HYDROXYBENZENES AND RELATED COMPOUNDS
- THE UPTAKE OF DOPAMINE-14C AND ITS CONVERSION TO NORADRENALINE-14C IN RATS
- THE EFFECTS OF RESERPINE ON THE SPONTANEOUS CONTRACTION OF THE ISOLATED ATRIUM OF RABBIT TREATED WITH MONOAMINE OXIDASE INHIBITORS
- FLUORESCENCE HISTOCHEMICAL FINDINGS OF THE STOMACH WALLS IN RESPONSE TO ULCEROGENIC STIMULI IN RATS
- FLUORESCENCE HISTOCHEMICAL DEMONSTRATION OF ADRENERGIC NERVE FIBERS IN THE VAGUS NERVE OF CATS AND DOGS
- HISTOCHEMICAL DEMONSTRATION OF NORADRENALINE IN RAT SALIVARY GLANDS
- EFFECTS OF THE ADRENERGIC DRUGS ON THE CHRONO- AND INOTROPIC RESPONSES TO THE CHOLINERGIC STIMULATION OF THE ISOLATED GUINEA-PIG'S ATRIA
- HISTOCHEMICAL DEMONSTRATION OF MONOAMINES IN THE THYMUS OF RATS
- EFFECTS OF VAGAL STIMULATION ON THE TRANSMEMBRANE ACTION POTENTIALS OF ATRIUM ISOLATED FROM GUINEA PIG
- MODIFICATIONS OF THE VAGAL EFFECT ON THE HEART AND THE CARDIAC METABOLISM BY RESERPINE IN VITRO
- EFFECTS OF TEMPERATURE CHANGE, OXYGEN DEPRIVATION AND CATIONS ON THE ATRIAL RESPONSES TO VAGAL STIMULATION
- EFFECTS OF 10-METHOXYDESERPIDINE AND RESERPINE ON THE SKIN AND RECTAL TEMPERATURE IN RABBITS
- DEPLETION OF ATRIAL NOREPINEPHRINE INDUCED BY RESERPINE IN VITRO
- TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS
- EFFECTS OF 10-METHOXYDESERPIDINE ON THE ECG CHANGES INDUCED BY VASOPRESSIN IN UNANESTHETIZED RABBIT
- THE EFFECT OF RESERPINE ON PHOSPHORYLASE ACTIVITY IN THE ISOLATED RABBIT ATRIA