EFFECTS OF 10-METHOXYDESERPIDINE AND RESERPINE ON THE SKIN AND RECTAL TEMPERATURE IN RABBITS

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Although the peripheral effects of reserpine are generally accepted, there is evidence to support the central action on the adrenal medulla (1-5). No depletion of tissue noradrenaline by 10-methoxydeserpidine (10-MD) has been reported in mice by Leroy and Schaepdryver (6). However, Higuchi <I>et al</I>. (7) have shown that the intravenous injection of 10-MD in rabbits depletes considerably the content of noradrenaline in the brain cortex, brain stem and heart, and of adrenaline in the adrenal medulla without manifesting sedation or diarrhea.<BR> 10-MD has recently been used clinically for the essential hypertension. Episode of the side effect that hyperemia and warm sensation of the face and neck manifest in some patients several hours after the oral administration has been reported (8). No such side effect has hitherto been reported in the case of reserpine. Therefore, the current report deals firstly with elucidation of action mechanism of the hyperemia and warm sensation in the face and neck caused by 10-MD, and secondarily with the pharmacological difference between reserpine and 10-MD. The results in the present experiments have shown that though reserpine produces a marked elevation of the ear temperature followed by a steady fall of the rectal temperature, 10-MD elicits a similar elevation of the ear temperature attended with no change in the rectal temperature in rabbits.
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