EFFECTS OF DECASERPINE ON THE CONTENT OF CATECHOLAMINE IN THE BRAIN, ATRIUM AND ADRENAL GLAND OF RABBIT
スポンサーリンク
概要
- 論文の詳細を見る
One of the side actions which restrict the clinical use of reserpine is a strong and long-lasting mental depression. Looking for other reserpine-like alkaloids less toxic and more useful for clinical trials than reserpine, Velluz <I>et al</I>. (1, 2) have presented 10-methoxydeserpidine (decaserpine), an isomer of reserpine.<BR> The pharmacological effects of decaserpine have been reported in detail by Mir and Lewis (3). When the initial blood pressure of an anesthetized cat was considerably high, the intravenous injection of decaserpine caused a gradual fall and bradycardia, and increased the pressor responses to adrenaline and noradrenaline. The intraperitoneal injection of 20 mg/kg of decaserpine did cause neither ptosis, diarrhea nor sedation in rats. In mice, however, the intraperitoneal injection of 40 to 80 mg/kg of decaserpine induced drowsiness and decrease of spontaneous motor activity in a similar manner to the appropriate dose of reserpine.<BR> On the other hand, Leroy and Schaepdryver (4) have reported that the intraperitoneal injection of 25 mg/kg of decaserpine did not affect the content of catecholamine in the brain and heart of cat 24 hours after the injection. In the previous report (5), the authors studied the time course of the depletion of noradrenaline in the brain and atrium, and of adrenaline in the adrenal glands of rabbit induced by the intravenous or intracarotid injection of reserpine.<BR> In this report, the effects of the intravenous and intracarotid injections of decaserpine on the content of noradrenaline and adrenaline in the tissues were likewise studied in rabbits. Besides, the same effects of tetrabenazine which has been reported to deplete less catecholamine from the peripheral organs than from the brain (6, 7), and of xylopinine which has been reported to show weak sedation and a considerably strong adrenolytic action in a variety of animals (8) were studied.
- 公益社団法人 日本薬理学会の論文
著者
-
島本 暉朗
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
中谷 〓二
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
樋口 秀雄
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
松尾 高明
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- THE MODE OF HYPOTENSIVE ACTIONS OF 2-(2, 6-DICHLOROPHENYL-L-AMINO)-IMIDAZOLINE IN THE RABBIT
- EFFECTS OF THIAMINE DERIVATIVES ON THE ATRIAL TRANSMEMBRANE POTENTIALS AND SPONTANEOUS CONTRACTION IN THE RABBIT
- EFFECTS OF N, N-DIPHENYLDICARBAMATE-1, 1-DEMETHYLOL CYCLOPENTANE (CAMALON) ON THE SPINAL CORD REFLEXES
- FATTY LIVER CAUSED BY THE REPETITIVE ADMINISTRATION OF RELATIVELY SMALL DOSES OF CARBON TETRACHLORIDE IN RATS
- EFFECTS OF CENTRAL DEPRESSANTS ON THE EVOKED POTENTIALS IN THE INFERIOR COLLICULUS CAUSED BY ACOUSTIC STIMULI IN THE CAT
- INHIBITION OF THE COMT ACTIVITY BY 1-(3, 4, 5-TRI-METHOXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHY-DROISOQUINOLINE AND 1-(3, 5-DIMETHOXY-4-HYDROXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHYDROISOQUINOLINE IN VITRO
- INHIBITION OF CATECHOL-O-METHYLTRANSFERASE BY HYDROXYBENZENES AND RELATED COMPOUNDS
- THE UPTAKE OF DOPAMINE-14C AND ITS CONVERSION TO NORADRENALINE-14C IN RATS
- THE EFFECTS OF RESERPINE ON THE SPONTANEOUS CONTRACTION OF THE ISOLATED ATRIUM OF RABBIT TREATED WITH MONOAMINE OXIDASE INHIBITORS
- THE EFFECT OF ADRENALINE ON THE PHOSPHORYLASE ACTIVITY OF THE HEART IN THE OPEN-CHEST RAT
- ELECTROENCEPHALOGRAPHIC STUDIES ON THIAMINE DERIVATIVES IN THE RABBIT
- THE CENTRAL ACTION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRATE
- FLUORESCENCE HISTOCHEMICAL FINDINGS OF THE STOMACH WALLS IN RESPONSE TO ULCEROGENIC STIMULI IN RATS
- FLUORESCENCE HISTOCHEMICAL DEMONSTRATION OF ADRENERGIC NERVE FIBERS IN THE VAGUS NERVE OF CATS AND DOGS
- EFFECTS OF DECASERPINE ON THE CONTENT OF CATECHOLAMINE IN THE BRAIN, ATRIUM AND ADRENAL GLAND OF RABBIT
- SPECIES DIFFERENCES OF SERUM AND LIVER CHOLESTEROL LEVELS BETWEEN RABBITS AND RATS FED ON HIGH-CHOLESTEROL DIET
- CENTRAL DEPRESSANTS AND EVOKED CLICK RESPONSES WITH SPECIAL REFERENCE TO THE RETICULAR FORMATION IN THE CAT
- CHRONIC ORAL TOXICITY OF 3, 5, 3'-TRIIODO-4'-ACETYLTHYROFORMIC ACID WITH SPECIAL REFERENCE TO CHOLESTEROLYTIC EFFECTS
- THE EFFECT OF PHYSOSTIGMINE ON HEART PHOSPHORYLASE ACTIVITY IN THE SPINAL RAT
- EFFECTS OF ETHYL-LINOLEATE ON THE ATHEROMATOUS CHANGES CAUSED BY HIGH CHOLESTEROL DIET IN THE RABBIT
- COMPARISON OF THE OPTICAL ISOMERS OF XYLOPININE
- EFFECTS OF THE ADRENERGIC DRUGS ON THE CHRONO- AND INOTROPIC RESPONSES TO THE CHOLINERGIC STIMULATION OF THE ISOLATED GUINEA-PIG'S ATRIA
- HISTOCHEMICAL DEMONSTRATION OF MONOAMINES IN THE THYMUS OF RATS
- EFFECTS OF TEMPERATURE CHANGE, OXYGEN DEPRIVATION AND CATIONS ON THE ATRIAL RESPONSES TO VAGAL STIMULATION
- EFFECTS OF CARNITINE ON THE SPONTANEOUS CONTRACTION AND THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S ATRIA
- THE EFFECTS OF THE ADRENOLYTICS ON THE CATECHOLAMINE CONTENT OF VARIOUS TISSUES IN RABBIT
- DEVELOPMENTAL ABNORMALITIES OF SKELETAL SYSTEM INDUCED BY ETHYLURETHAN IN THE RAT
- EFFECTS OF 10-METHOXYDESERPIDINE AND RESERPINE ON THE SKIN AND RECTAL TEMPERATURE IN RABBITS
- EFFECTS OF SKF-385 AND RESERPINE ON THE TISSUE CATECHOLAMINE CONTENT IN RABBITS
- DEPLETION OF ATRIAL NOREPINEPHRINE INDUCED BY RESERPINE IN VITRO