FATTY LIVER CAUSED BY THE REPETITIVE ADMINISTRATION OF RELATIVELY SMALL DOSES OF CARBON TETRACHLORIDE IN RATS

概要

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There have been numerous biochemical and histological studies on the diffusely developed fatty liver regard as the model of disturbance of the liver function. However, the single oral administration of carbon tetrachloride (CCl4) in relatively larger doses produces the diffuse fatty degeneration of liver within 24 hours after the treatment. Moreover, the degree of the fatty liver is not reliable to the doses of CCl4 and the recovery from the degeneration is subjected to much individual variation. The present experiment is a device to establish a dose-response relationship in the development of fatty liver by the repeated oral administration of the doses of CCl4, which did not affect the activity of liver enzyme such as GOT in the single doses. The effects of CCl4 on lipid metabolism of the liver and blood as well as histological changes of the parenchymatous organs were observed at various term after the treatment.
社団法人日本薬理学会の論文