EFFECTS OF SKF-385 AND RESERPINE ON THE TISSUE CATECHOLAMINE CONTENT IN RABBITS
スポンサーリンク
概要
- 論文の詳細を見る
The intravenous injection of 0.5 to 3.0 mg/kg of <I>traps</I>-2-phenylcyclopropylamine maleate (SKF-385) in the anesthetized dog produces the pressor effect which is prevented by the adrenolytic doses of tolazoline and dibenamine (1). However, the repetition of the doses of SKF-385 exerts the depressor effect which is totally abolished by the pretreatment with reserpine. The results indicate that the pressor effect relates with the release of the endogenous noradrenaline, while the depressor effect relates with the presence of the endogenous noradrenaline in the circulatory organs. The accumulation of the endogenous catecholamine after administration of monoamine oxidase (MAO) inhibitor has been shown in the central nervous system (2-4) and in the heart (5-7). On the other hand, the administration of iproniazid has been reported to produce no significant change of the brain noradrenaline in rabbit (8, 9) and of the heart noradrenaline in rabbit and mouse (9, 10). Goldberg and Shideman (11) have shown that the myocardial noradrenaline in cat decreases significantly in response to 2 to 30 mg/kg of SKF385, while that in rat increases markedly.<BR> Tachi, Nakatani and Fujiwara (12) have studied the effects of reserpine on the isolated atrial preparation of rabbit pretreated with the MAO inhibitors. The atrium of rabbit pretreated with <I>beta</I>-phenylisopropylamine or SKF-385, either of which alone produces the positive inotropic and 'chronotropic effects, has responded to reserpine with the depressor effect, while the atrium of rabbit pretreated with iproniazid has responded to reserpine with the augmenting effect. The results prompted to study the changes of catecholamine in the tissues including brain, heart, spleen and adrenal glands in the rabbit which received SKF-385 alone or reserpine after the pretreatment with SKF-385.
- 公益社団法人 日本薬理学会の論文
著者
-
島本 暉朗
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
服部 圭佑
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
本庄 俊
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
松尾 高明
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- THE MODE OF HYPOTENSIVE ACTIONS OF 2-(2, 6-DICHLOROPHENYL-L-AMINO)-IMIDAZOLINE IN THE RABBIT
- EFFECTS OF THIAMINE DERIVATIVES ON THE ATRIAL TRANSMEMBRANE POTENTIALS AND SPONTANEOUS CONTRACTION IN THE RABBIT
- EFFECTS OF N, N-DIPHENYLDICARBAMATE-1, 1-DEMETHYLOL CYCLOPENTANE (CAMALON) ON THE SPINAL CORD REFLEXES
- FATTY LIVER CAUSED BY THE REPETITIVE ADMINISTRATION OF RELATIVELY SMALL DOSES OF CARBON TETRACHLORIDE IN RATS
- PHARMACOLOGICAL ACTION OF OCTOPAMINE WITH SPECIAL REFERENCE TO BIOCHEMICAL CONVERSION TO NORADRENALINE
- EFFECTS OF CENTRAL DEPRESSANTS ON THE EVOKED POTENTIALS IN THE INFERIOR COLLICULUS CAUSED BY ACOUSTIC STIMULI IN THE CAT
- INHIBITION OF THE COMT ACTIVITY BY 1-(3, 4, 5-TRI-METHOXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHY-DROISOQUINOLINE AND 1-(3, 5-DIMETHOXY-4-HYDROXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHYDROISOQUINOLINE IN VITRO
- INHIBITION OF CATECHOL-O-METHYLTRANSFERASE BY HYDROXYBENZENES AND RELATED COMPOUNDS
- THE UPTAKE OF DOPAMINE-14C AND ITS CONVERSION TO NORADRENALINE-14C IN RATS
- ELECTROENCEPHALOGRAPHIC STUDIES ON THIAMINE DERIVATIVES IN THE RABBIT
- THE CENTRAL ACTION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRATE
- FLUORESCENCE HISTOCHEMICAL FINDINGS OF THE STOMACH WALLS IN RESPONSE TO ULCEROGENIC STIMULI IN RATS
- FLUORESCENCE HISTOCHEMICAL DEMONSTRATION OF ADRENERGIC NERVE FIBERS IN THE VAGUS NERVE OF CATS AND DOGS
- EFFECTS OF DECASERPINE ON THE CONTENT OF CATECHOLAMINE IN THE BRAIN, ATRIUM AND ADRENAL GLAND OF RABBIT
- SPECIES DIFFERENCES OF SERUM AND LIVER CHOLESTEROL LEVELS BETWEEN RABBITS AND RATS FED ON HIGH-CHOLESTEROL DIET
- CENTRAL DEPRESSANTS AND EVOKED CLICK RESPONSES WITH SPECIAL REFERENCE TO THE RETICULAR FORMATION IN THE CAT
- CHRONIC ORAL TOXICITY OF 3, 5, 3'-TRIIODO-4'-ACETYLTHYROFORMIC ACID WITH SPECIAL REFERENCE TO CHOLESTEROLYTIC EFFECTS
- EFFECTS OF ETHYL-LINOLEATE ON THE ATHEROMATOUS CHANGES CAUSED BY HIGH CHOLESTEROL DIET IN THE RABBIT
- HISTOCHEMICAL DEMONSTRATION OF NORADRENALINE IN RAT SALIVARY GLANDS
- COMPARISON OF THE OPTICAL ISOMERS OF XYLOPININE
- EFFECTS OF THE ADRENERGIC DRUGS ON THE CHRONO- AND INOTROPIC RESPONSES TO THE CHOLINERGIC STIMULATION OF THE ISOLATED GUINEA-PIG'S ATRIA
- HISTOCHEMICAL DEMONSTRATION OF MONOAMINES IN THE THYMUS OF RATS
- MODIFICATIONS OF THE VAGAL EFFECT ON THE HEART AND THE CARDIAC METABOLISM BY RESERPINE IN VITRO
- EFFECTS OF TEMPERATURE CHANGE, OXYGEN DEPRIVATION AND CATIONS ON THE ATRIAL RESPONSES TO VAGAL STIMULATION
- EFFECTS OF CARNITINE ON THE SPONTANEOUS CONTRACTION AND THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S ATRIA
- THE EFFECTS OF THE ADRENOLYTICS ON THE CATECHOLAMINE CONTENT OF VARIOUS TISSUES IN RABBIT
- DEVELOPMENTAL ABNORMALITIES OF SKELETAL SYSTEM INDUCED BY ETHYLURETHAN IN THE RAT
- EFFECTS OF 10-METHOXYDESERPIDINE AND RESERPINE ON THE SKIN AND RECTAL TEMPERATURE IN RABBITS
- EFFECTS OF SKF-385 AND RESERPINE ON THE TISSUE CATECHOLAMINE CONTENT IN RABBITS
- DEPLETION OF ATRIAL NOREPINEPHRINE INDUCED BY RESERPINE IN VITRO
- EFFECTS OF SINGLE AND REPEATED INJECTION OF METHAMPHETAMINE ON THE TISSUE CATECHOLAMINE OF RABBIT
- THE UPTAKE OF NORADRENALINE BY TISSUES AFTER THE CONTINUOUS INFUSION TO RABBIT