FLUORESCENCE HISTOCHEMICAL DEMONSTRATION OF ADRENERGIC NERVE FIBERS IN THE VAGUS NERVE OF CATS AND DOGS
スポンサーリンク
概要
- 論文の詳細を見る
The cervial vagus nerves of the mammalians are known to be composed of the following five, functionally different fibers: <I>1</I>) general somatic afferent fibers, <I>2</I>) general visceral afferent fibers, <I>3</I>) specific visceral afferent fibers, <I>4</I>) general visceral efferent fibers and <I>5</I>) specific visceral efferent fibers (1). The general visceral efferent fibers originating from the dorsal motor nucleus of the vagus in the medulla oblongata are regarded to be cholinergic in nature. But fluorescence histochemical studies showed that green-fluorescent noradrenaline terminals became visible in the part of this nucleus after giving <I>1</I>-dopa to rats (2). Cholinergic impulses conducted in the vagus nerve give rise to the inhibition of cardiac rate and contractility, the relaxation of gastrointestinal sphincters and also to the increase of gastrointestinal motility and tone. However, since the demonstration by McEwen (3) that electrical stimulation of the vagus nerve to the isolated rabbit atria resulted in the increase in cardiac rate and contractility under the presence of hexamethonium, evidence to confirm the dual responses of the heart to vagal stimulation is accumulating in cats (4), rabbits (5-7) and guinea pigs (8) under various experimental conditions. Jellinek <I>et al</I>. (9) have shown that bilateral cervical vagosympathectomy results in a significant reduction of cardiac catecholamine if dogs survived surgery. The results are rather indicative of the contribution of the vagus nerves to retaining the endogenous noradrenaline in the heart. The demonstration by Hamberger and Norberg (10) that the pelvic nerve of the cat, known to be pure cholinergic in nature, contained the noradrenaline-fluorescent fibers stimulated the authors to perform the present experiments. The vagus nerve of the cat, readily separable from the cervical sympathetic nerve, and also the same nerve of the dog constituting the vagosympathicus were found to contain the noradrenali ne-fluorescent fibers.
- 公益社団法人 日本薬理学会の論文
著者
-
藤原 元始
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
島本 暉朗
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
無量林 堯
Department of Pharmacology, Faculty of Medicine, Kyoto University
-
森 襄
Department of Pharmacology, Faculty of Medicine, Kyoto University
関連論文
- RESPONSE TO SYMPATHETIC NERVE STIMULATION AND NORADRENALINE IN ATRIA TREATED WITH RESERPINE AND IN ATRIA FROM RABBITS PRETREATED WITH RESERPINE
- THE MODE OF HYPOTENSIVE ACTIONS OF 2-(2, 6-DICHLOROPHENYL-L-AMINO)-IMIDAZOLINE IN THE RABBIT
- EFFECTS OF THIAMINE DERIVATIVES ON THE ATRIAL TRANSMEMBRANE POTENTIALS AND SPONTANEOUS CONTRACTION IN THE RABBIT
- EFFECTS OF N, N-DIPHENYLDICARBAMATE-1, 1-DEMETHYLOL CYCLOPENTANE (CAMALON) ON THE SPINAL CORD REFLEXES
- FATTY LIVER CAUSED BY THE REPETITIVE ADMINISTRATION OF RELATIVELY SMALL DOSES OF CARBON TETRACHLORIDE IN RATS
- FLUOROMETRIC ASSAY OF TISSUE HISTAMINE
- PHARMACOLOGICAL ACTION OF OCTOPAMINE WITH SPECIAL REFERENCE TO BIOCHEMICAL CONVERSION TO NORADRENALINE
- EFFECTS OF CENTRAL DEPRESSANTS ON THE EVOKED POTENTIALS IN THE INFERIOR COLLICULUS CAUSED BY ACOUSTIC STIMULI IN THE CAT
- INHIBITION OF THE COMT ACTIVITY BY 1-(3, 4, 5-TRI-METHOXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHY-DROISOQUINOLINE AND 1-(3, 5-DIMETHOXY-4-HYDROXYBENZYL)-6, 7-DIHYDROXY-1, 2, 3, 4-TETRAHYDROISOQUINOLINE IN VITRO
- INHIBITION OF CATECHOL-O-METHYLTRANSFERASE BY HYDROXYBENZENES AND RELATED COMPOUNDS
- THE UPTAKE OF DOPAMINE-14C AND ITS CONVERSION TO NORADRENALINE-14C IN RATS
- THE EFFECTS OF RESERPINE ON THE SPONTANEOUS CONTRACTION OF THE ISOLATED ATRIUM OF RABBIT TREATED WITH MONOAMINE OXIDASE INHIBITORS
- ELECTROENCEPHALOGRAPHIC STUDIES ON THIAMINE DERIVATIVES IN THE RABBIT
- THE CENTRAL ACTION OF GAMMA-BUTYROLACTONE AND GAMMA-HYDROXYBUTYRATE
- FLUORESCENCE HISTOCHEMICAL FINDINGS OF THE STOMACH WALLS IN RESPONSE TO ULCEROGENIC STIMULI IN RATS
- FLUORESCENCE HISTOCHEMICAL DEMONSTRATION OF ADRENERGIC NERVE FIBERS IN THE VAGUS NERVE OF CATS AND DOGS
- EFFECTS OF DECASERPINE ON THE CONTENT OF CATECHOLAMINE IN THE BRAIN, ATRIUM AND ADRENAL GLAND OF RABBIT
- SPECIES DIFFERENCES OF SERUM AND LIVER CHOLESTEROL LEVELS BETWEEN RABBITS AND RATS FED ON HIGH-CHOLESTEROL DIET
- CENTRAL DEPRESSANTS AND EVOKED CLICK RESPONSES WITH SPECIAL REFERENCE TO THE RETICULAR FORMATION IN THE CAT
- CHRONIC ORAL TOXICITY OF 3, 5, 3'-TRIIODO-4'-ACETYLTHYROFORMIC ACID WITH SPECIAL REFERENCE TO CHOLESTEROLYTIC EFFECTS
- EFFECTS OF ETHYL-LINOLEATE ON THE ATHEROMATOUS CHANGES CAUSED BY HIGH CHOLESTEROL DIET IN THE RABBIT
- HISTOCHEMICAL DEMONSTRATION OF NORADRENALINE IN RAT SALIVARY GLANDS
- COMPARISON OF THE OPTICAL ISOMERS OF XYLOPININE
- EFFECTS OF THE ADRENERGIC DRUGS ON THE CHRONO- AND INOTROPIC RESPONSES TO THE CHOLINERGIC STIMULATION OF THE ISOLATED GUINEA-PIG'S ATRIA
- HISTOCHEMICAL DEMONSTRATION OF MONOAMINES IN THE THYMUS OF RATS
- EFFECTS OF VAGAL STIMULATION ON THE TRANSMEMBRANE ACTION POTENTIALS OF ATRIUM ISOLATED FROM GUINEA PIG
- MODIFICATIONS OF THE VAGAL EFFECT ON THE HEART AND THE CARDIAC METABOLISM BY RESERPINE IN VITRO
- EFFECTS OF TEMPERATURE CHANGE, OXYGEN DEPRIVATION AND CATIONS ON THE ATRIAL RESPONSES TO VAGAL STIMULATION
- EFFECTS OF CARNITINE ON THE SPONTANEOUS CONTRACTION AND THE TRANSMEMBRANE POTENTIALS OF THE ISOLATED RABBIT'S ATRIA
- THE EFFECTS OF THE ADRENOLYTICS ON THE CATECHOLAMINE CONTENT OF VARIOUS TISSUES IN RABBIT
- DEVELOPMENTAL ABNORMALITIES OF SKELETAL SYSTEM INDUCED BY ETHYLURETHAN IN THE RAT
- EFFECTS OF 10-METHOXYDESERPIDINE AND RESERPINE ON THE SKIN AND RECTAL TEMPERATURE IN RABBITS
- EFFECTS OF SKF-385 AND RESERPINE ON THE TISSUE CATECHOLAMINE CONTENT IN RABBITS
- DEPLETION OF ATRIAL NOREPINEPHRINE INDUCED BY RESERPINE IN VITRO
- TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS
- EFFECTS OF 10-METHOXYDESERPIDINE ON THE ECG CHANGES INDUCED BY VASOPRESSIN IN UNANESTHETIZED RABBIT
- THE EFFECT OF RESERPINE ON PHOSPHORYLASE ACTIVITY IN THE ISOLATED RABBIT ATRIA