Protective Effects of the Antianginal Agent Nicorandil on Arachidonate-Induced Sudden Death in Rats: Comparison with Several Antianginal Agents and Cyclooxygenase Inhibitors
スポンサーリンク
概要
- 論文の詳細を見る
In anesthetized rats, intra-carotid injections of arachidonate·Na (20 mg/kg) elicited a marked pressor response, producing death within 10 min in untreated rats. The antianginal agents (nicorandil, nitroglycerin and diltiazem) and cyclooxygenase inhibitors (indomethacin and aspirin), applied i.v. or p.o., effectively protected the rats from death. In the surviving rats, these drugs significantly prevented intravascular thrombosis in cerebral vessels and the marked pressor response to arachidonate·Na. The protective mechanism of the antianginal agents tested seems to be different from that of cyclooxygenase inhibitors.
- 公益社団法人 日本薬理学会の論文
著者
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Sugimoto Tetsuro
Department Of Pathology Keio University School Of Medicine
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Nakamura Yasuyuki
Department Of Biological Science And Technology Science University Of Tokyo
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SAKAI Kazushige
Departinent of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co.
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SAKAI Kazushige
Departments of Pharmacology, Chugai Pharmaceutical Co., Ltd.
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YAMAZAKI Tamotsu
Departments of Pharmacology, Chugai Pharmaceutical Co., Ltd.
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SUGIMOTO Tetsuro
Departments of Pathology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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YAMAZAKI Tamotsu
Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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NAKAMURA Yasuyuki
Departments of Pharmacology, Chugai Pharmaceutical Co., Ltd.
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