Effects of a new anti-inflammatory imidazole derivative, fenflumizole, on platelet aggregation in the rabbit.
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概要
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The antiplatelet effect of fenflumizole, compared with aspirin or ticlopidine, was examined in in vitro, ex vivo and in vivo situations of the rabbit. Unlike ticlopidine, fenflumizole and aspirin effectively inhibited in vitro the platelet aggregation elicited by arachidonate and collagen. The activity of fenflumizole was 350 times more potent than that of aspirin. Fenflumizole (0.3-3 mg/kg) given p.o. was 4.2 and 8.1 times more potent than aspirin in inhibiting arachidonate and collagen-induced platelet aggregations, respectively. Ticlopidine (300 mg/kg, p.o.) resulted in only weak effects on the aggregations. Fenflumizole (3 mg/kg) as well as aspirin (10 mg/kg) given p.o., unlike ticlopidine (300 mg/kg), effectively prevented the arachidonate-induced sudden death.
- 公益社団法人 日本薬理学会の論文
著者
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AONO Junichiro
Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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NABATA Hiroyuki
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SAKAI Kazushige
Departinent of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co.
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AONO Junichiro
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University
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