DEVELOPMENT OF TOLERANCE AND A NEW CORONARY VASODILATOR, N-(2-HYDROXYETHYL)NICOTINAMIDE NITRATE (SG-75): A COMPARISON WITH NITROGLYCERIN
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概要
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Tolerance to N-(2-hydroxyethyl)nicotinamide nitrate (SG-75) and nitroglycerin (NTG) was studied in rats with regard to the blood pressure responses <I>in vivo</I> and thoracic aorta strip preparations <I>in vitro</I>. Tolerance to the blood pressure response to SG-75 or NTG was observed with consecutive subcutaneous administrations of high doses of SG-75 or NTG, three times a day and the tolerance was time- and dose-dependent. In strips of the aorta incubated for 30 min with SG-75, sensitivity to challenging doses of SG-75 remained unchanged, but in the preparations incubated with NTG, the response to challenging doses of NTG was greatly decreased. SG-75 developed no cross tolerance to NTG. In <I>in vivo</I> experiments, SG-75 developed only slight tolerance, but in the <I>in vitro</I> experiments, unlike NTG, induced no tolerance.
- 社団法人 日本薬理学会の論文
著者
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SAKAI Kazushige
Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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NABATA Hiroyuki
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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SHIRAKI Yasuyuki
Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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SHIRAKI Yasuyuki
Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co.
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SAKAI Kazushige
Departinent of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co.
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NABATA Hiroyuki
Department of Pharmacology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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