鼻粘膜刺激と肺抵抗 : 特にアトロピン投与の影響について

概要

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The respiratory effect of mild irritants to the nasal mucous membrane has been studied by a number of researchers. Some investigators have reported an increase in pulmonary resistance; Others have noted a decrease. This study was undertaken to learn whether stimulation to the receptors site in the nose can initiate an increase or decrease in tracheobronchial airflow resistance in man. The experiments were made on 12 laryngectomized patients ranging in age from 50 to 77 years. The measurements before and after irritation of the nasal mucosa were obtained as follows:1) during normal breathing, 2) after swab stick stimulation for right nose, 3) after swab stick stimulation for left nose. In addition, all subjects received 0. 5mg atropine sulfate subcutaneously, and 25 minutes later the same measurements were performed before and after nasal stimulation. Lower pulmonary resistance decreased after irritation of the nasal mucosa. Injection of atropine caused greater decrease of lower pulmonary resistance after nasal stimulation. This decrease in pulmonary resistance suggests that bronchial dilatation occurred. Our study demonstrated that a reflex arc existed between the nose and the lungs in laryngec. tomized patients.
社団法人日本耳鼻咽喉科学会の論文