II. Pathological Observation of Perianal Pagetoid Lesion

概要

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Six cases of perianal Paget disease are reported. Each cases showed underlying carcinoma, including-one case of sweat gland carcinoma, two cases of anal mucinous adenocarcinoma and three cases of rectal carcinoma. Underlying carcinoma and Paget's cells were examined histologically and histochemically.<BR>Anal mutinous adenocarcinoma, sweat gland carcinoma and Paget cells was chara-cterized by PAS reactivity that was completely abolished after Periodate Borohydride Saponification (PB/KOH), while, rectal cancer cases showed strongly positive PB/KOH/PAS staining, both in underlying carcinoma and in Paget cells in affected anal and perianal skin.<BR>The results indicated that PB/KOH/PAS method may be of value in differentiating between Paget's cells arising in anal mucinous adenocarcinoma and in rectal adenocarcinoma.
日本大腸肛門病学会の論文