中枢性鎮痛薬の依存性に関する研究 : 第4報Codeine依存白鼠における副腎皮質束状層細胞内の電子顕微鏡的変化について

概要

論文の詳細を見る
Influences of codeine on the fine structure of zona fasciculata of rat adrenal cortex electron microscopically were studied. The results obtained are as follows. Administering codeine at a dosage of 40mg/kg to normal rats, the honeycombed structures of inner membranes of mitochondria in adrenocortical cells gradually disappeared and the matrix of mitochondria became to less dense. While the deformed structures above-mentioned gradually diminished during the chronic administration of the drug. However, the deformation of inner membranes in mitochondria were produced again in tolerant rats after withdrawal of codeine or treatment of levallorphan, but after the reinjection of codeine, the changes disappeared to the normal state.