RU486投与によるラットの着床阻害〔英文〕

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A single oral administration of RU 486 (50mg/kg), an antiprogesterone compound, inhibited implantation in early pregnant rats. Under this conditions, the effects of RU 486 on structure of the uterine epithelial surface, on recovery and development of embryos, and on decidualization were examined. The observation of the uterine epithelial surface was performed with a scanning electron microscope. In untreated rats with RU 486 (control) at 16: 00 on Day 5 of pregnancy, cytoplasmic protrusions in the epithelial surface appeared in various types of shape with clear margin and were 1-5μm in diameter.On the other hand, the remarkable changes of these protrusions in shape were observed at the earlier phase of administration of RU486. The large(>3μm)and medium (1.5-3μm) size of the protrusions decreased gradually in mean number per 2, 500μm2 of the uterine surface after the administration of RU486. Fertilized eggs of the rats received RU 486 could be found without any morphological damages under a microscope in the uterine lumens and about 85% of the embryos recovered from the lumen developed from 16-cell to blastocyst in one or two days with a microdroplet culture. Furthermore, implantation rate and number of implantation sites decreased as hours passed after the administration of RU 486. In rats decidualized by injection of sesame oil on Day 5 of udopregnancy, mean weight of oilinjected uterine horns of rats received RU 486 on Day 7 or Day 8 had significant decrease on Day 9 in comparison with control(P<0.O1, and P<0.05 respectively). From these results, we concluded that RU 486 as an antiprogesterone compound had specific and potent actions to inhibit the development of the cytoplasmic protrusions and the decidual response in uterine endometrium in rat while the corpora lutea were functional.

RU486投与によるラットの着床阻害〔英文〕

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