Behavior of β-tricalcium phosphate granules composed of rod-shaped particles in the rat tibia
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概要
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Porous spherical granules of β-tricalcium phosphate (β-TCP) composed of rod-shaped particles were prepared via a hydrothermal route. The biological significance of implantation of the spherical β-TCP granules for healing of bone defects was analyzed by implantation into 2 mm diameter and 3 mm deep defects created in tibiae of 9-week-old Wistar rats. Implantation of spherical β-TCP contributed to regeneration of bone tissue. At 2 and 4 weeks after implantation, numerous alkaline phosphatase-positive cells appeared around the implant and newly formed bone. At 8 weeks after implantation, residual implants were mostly embedded in bone tissue. Without implantation, bone defects healed with a much lower amount of bone. In addition, bone marrow adipocytes were considerably fewer in tibiae with implants compared to tibiae without implants at 4 and 8 weeks after the operation. These data suggested that implanted β-TCP granules worked as scaffolds to maintain alkaline phosphatase-positive cells and also resulted in less fatty change of bone marrow.
著者
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KAMITAKAHARA Masanobu
Graduate School of Environmental Studies, Tohoku University
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Kamitakahara Masanobu
Graduate School Of Environmental Studies Tohoku Univ.
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KUROSAWA Hisashi
Department of Orthopaedics Surgery, Juntendo University School of Medicine
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IKEDA Tohru
Department of Pathology and Immunology, Graduate School, Tokyo Medical and Dental University
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IOKU Koji
Graduate School of Environmental Studies, Tohoku University
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OKUMURA Teruhito
Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences
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GONDA Yoshinori
Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical
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OKUDA Takatoshi
Department of Orthopedic Surgery, School of Medicine, Juntendo University
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YONEZAWA Ikuho
Department of Orthopedic Surgery, School of Medicine, Juntendo University
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ASAHINA Izumi
Department of Regenerative Oral Surgery, Nagasaki University Graduate School of Biomedical Sciences
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Ioku Koji
Graduate School Of Environmental Studies Tohoku Univ.
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Kurosawa Hisashi
Department Of Neuropsychiatry Nippon Medical School Chiba Hokusoh Hospital
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Yonezawa Ikuho
Department Of Orthopaedic Surgery School Of Medicine Juntendo University
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Asahina Izumi
Department Of Regenerative Oral Surgery Nagasaki University Graduate School Of Biomedical Sciences
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Ikeda Tohru
Department Of Oral Pathology And Bone Metabolism Unit Of Basic Medical Sciences Course Of Medical An
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Kurosawa Hisashi
Department Of General Surgery Chiba University Graduate School Of Medicine
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池田 通
長崎大学大学院医歯薬学総合研究科
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IKEDA Tohru
Department of Oral Pathology and Bone Metabolism, Nagasaki University Graduate School of Biomedical Sciences
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Okuda Takatoshi
Department of Material Science and Engineering, Nagoya Institute of Technology
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Gonda Yoshinori
Department of Oral Pathology and Bone Metabolism, Basic Medical Sciences Unit, Nagasaki University Graduate School of Biomedical Sciences
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