Formation of hydroxyapatite on ceramics consisting of tricalcium phosphate in a simulated body fluid(<Feature> Ceramics for Biomedical Applications in Asian Countries)
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概要
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Tricalcium phosphate (TCP) is used as biodegradable bone substitutes. When TCP is implanted in a bony defect, it is gradually decomposed in living body, and finally substituted by living bone tissue. Solubility of α-phase of TCP (α-TCP) is higher than that of β-phase (β-TCP), and hence the degradation of α-TCP is faster than that of β-TCP. Recently, we fabricated α-TCP porous ceramic with continuous pores in the range of 10-50μm as highly bioabsorbable bone fillers. The rate of bioabsorption was controlled by combination of β-TCP with α-TCP. Although the TCP ceramic is suggested to form hydroxyapatite in a simulated body fluid (SBF), the ability of the apatite formation is affected not only by the phase contents, but also by the porosity of the ceramics. In this study, we fundamentally investigated behavior of the hydroxyapatite formation on α-TCP ceramics with different surface and biphasic TCP ceramic in SBF proposed by Kokubo et al. Hydroxyapatite formation was observed on the surface of the biphasic TCP consisting of α-TCP and β-TCP, after soaking in SBF. The surface of the polished α-TCP ceramic showed the hydroxyapatite formation, but the surface of the as-sintered α-TCP ceramic did not. The polished surface of the α-TCP ceramic acted as a significant parameter on the hydroxyapatite formation in body environment. Thus, the polishing of the surface allows the osteoconductivity due to the potential of the hydroxyapatite formation on their surfaces in body environment.
- 社団法人日本セラミックス協会の論文
- 2008-01-01
著者
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KAMITAKAHARA Masanobu
Graduate School of Environmental Studies, Tohoku University
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OHTSUKI Chikara
Graduate school of Engineering, Nagoya University
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Kamitakahara Masanobu
Graduate School Of Environmental Studies Tohoku University
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Kamitakahara Masanobu
Graduate School Of Environmental Studies Tohoku Univ.
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Uchino Tomohiro
Musashino Univ. Tokyo Jpn
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Uchino Tomohiro
Graduate School Of Engineering Nagoya University
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Ohtsuki Chikara
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Ohtsuki Chikara
Graduate School Of Engineering Nagoya Univ.
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Ohtsuki C
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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Ohtsuki Chikara
Dep. Of Crystalline Materials Sci. Graduate School Engineering Nagoya Univ.
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Ohtsuki Chikara
奈良先端科学技術大学院大学 物質創成科学研究科
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KAWACHI Giichiro
Department of Biomaterials, Faculty of Dental Science, Kyushu University
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Kawabata Koji
Industrial Technol. Center Of Okayama Prefecture
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Ohtsuki Chikara
Graduate School Of Engineering Nagoya University
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KAWACHI Giichiro
Graduate School of Engineering, Nagoya University
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KIKUTA Koichi
Graduate School of Engineering, Nagoya University
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YAMAGUCHI Kohei
Graduate school of Engineering, Nagoya University
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Yamaguchi Kohei
Graduate School Of Engineering Nagoya University
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Kawabata Koji
Department Of Crystalline Materials Science Graduate School Of Engineering Nagoya University
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