Development of a Bone-Repairing Material Through Hybridization of Biodegradable Polymer with Bone-like Apatite(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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Hybrids consisting of biodegradable polysaccharide scaffold coated with bone-like apatite are expected to show both biodegradability and bone-bonding ability, i.e. bioactivity. This study is focused on a coating method of bone-like apatite on alginate. In this study, we proposed modification of alginate with silanol groups (Si-OH), followed by a treatment with calcium chloride solution. The modified alginate gel was successfully coated with bone-like apatite in a biomimicking solution to body fluid. Bone-like apatite layer was successfully coated on the surface of the modified alginate. This technique enables us to produce the hybrids consisting polymer and bone-like apatite with biodegradability and bioactivity for bone repair.
硬組織再生生物学会の論文