Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
スポンサーリンク
概要
- 論文の詳細を見る
A growing body of evidence suggests that nobiletin (5,6,7,8,3′,4′-hexamethoxy flavone) from the peel of citrus fruits, enhances the damaged cognitive function in disease animal models. However, the neuroprotective mechanism has not been clearly elucidated. Since nobiletin has shown anti-inflammatory effects in several tissues, we investigated whether nobiletin suppresses excessive microglial activation implicated in neurotoxicity in lipopolysaccharide (LPS)-stimulated BV-2 microglia cell culture models. Release of nitric oxide (NO), the major inflammatory mediator in microglia, was markedly suppressed in a dose-dependent manner following nobiletin treatment (1—50 μM) in LPS-stimulated BV-2 microglia cells. The inhibitory effect of nobiletin was similar to that of minocycline, a well-known microglial inactivator. Nobiletin significantly inhibited the release of the pro-inflammatory cytokine tumor necrosis factor (TNF-α) and interleukin-1β (IL-1β). LPS-induced phosphorylations of extracellular signal-regulated kinase (ERK), c-Jun NH2-terminal kinase (JNK), and p38 mitogen-activated protein kinases (MAPKs) were also significantly inhibited by nobiletin treatment. In addition, nobiletin markedly inhibited the LPS-induced pro-inflammatory transcription factor nuclear factor κB (NF-κB) signaling pathway by suppressing nuclear NF-κB translocation from the cytoplasm and subsequent expression of NF-κB in the nucleus. Taken together, these results may contribute to further exploration of the therapeutic potential and molecular mechanism of nobiletin in relation to neuroinflammation and neurodegenerative diseases.
- 公益社団法人 日本薬学会の論文
著者
-
KIM Sang
Department of Metallic and Materials Engineering, Gyeongsang National University
-
KIM Se-Jae
Department of Life Science, Cheju National University
-
Cui Yanji
Institute of Medical Science, Jeju National University School of Medicine
-
Wu Jinji
Institute of Medical Science, Jeju National University School of Medicine
-
Jung Sung-Cherl
Institute of Medical Science, Jeju National University School of Medicine
-
Park Deok-Bae
Institute of Medical Science, Jeju National University School of Medicine
-
Maeng Young-Hee
Institute of Medical Science, Jeju National University School of Medicine
-
Hong Jeong
Institute of Medical Science, Jeju National University School of Medicine
-
Lee Sun-Ryung
Department of Biology, Jeju National University
-
Kim Soon-Jong
Department of Chemistry, Mokpo National University
-
Eun Su-Yong
Institute of Medical Science, Jeju National University School of Medicine
-
Kim Sang
Department Of Chem. Eng. The University Of Seoul
-
Kim Se-jae
Department Of Biology Jeju National University
-
KIM Sang
Department of Anesthesiology and Pain Medicine, Chosun University Medical School
-
Kim Sang
Department of Physiology and Biophysics, Seoul National University College of Medicine
関連論文
- 銅/グラファイト界面の化学結合状態に対する添加元素効果
- P1-IS-48 Diabetes Mellitus Following Platinum-Based Chemotherapy in Patients with Gynecologic Malignancy
- P1-IS-38 The Safety and Efficacy of Belotecan in Patients with Recurrent or Refractory Ovarian Cancer
- P1-IS-6 The mRNA and protein expressions of cell division cycle 25 phosphatase in cervical carcinoma and their correlations with clinicopathologic factors
- P-IS-44 Correlation of HLA-G gene Expression with Various Prognostic Factors in Ovarian Carcinoma(Oncology 12,Group 99,International Session)
- P-IS-41 Analysis of Chromosomal Changes in Serous Ovarian Carcinoma by Microarray Comparative Genomic Hybridization : Potential Predictive Markers for Chemoresistant Disease(Oncology 11,Group 98,International Session)
- S2c1-1 Structure and Ribonuclease Activity of Pelota : Implications for the No-go Decay and Translation Regulation(S2-c1: "Crystallographic approach to understand biological supramacromolecular assemblies",Symposia,Abstract,Meeting Program of EABS & BSJ 2
- Correlation between Flavonoid Content and the NO Production Inhibitory Activity of Peel Extracts from Various Citrus Fruits(Miscellaneous)
- The C-terminal Tail of Mitochondrial Transcription Factor A Markedly Strengthens its General Binding to DNA
- Early Changes in Biochemical Markers of Bone Turnover Predict Bone Mineral Density Response to Antiresorptive Therapy in Korean Postmenopausal Women with Osteoporosis
- Conduction Behavior of SrBi_2Ta_2O_9 Thin Film Grown by Pulsed Laser Deposition
- Highly Anisotropic Etching of Tungsten-Nitride for an X-Ray Mask Absorber with an Inductively Coupled Plasma System
- Isolation of 19 strains of Malassezia dermatis from healthy human skin in Korea
- Majocchi's granuloma in a woman with iatrogenic Cushing's syndrome
- Post-steroid panniculitis in an adult
- Optical Property of PtO_x at Elevated Temperatures Investigated by Ellipsometry
- ^F-FDG PET imaging of progressive massive fibrosis
- Dielectric Properties of Poly(enaminonitrile)s
- Decoherence from Internal Dynamics in Macroscopic Matter-Wave Interferometry(Atomic and Molecular Physics)
- Photochemical and Redox Switching in a Ring-closed Isomer of Thioindigo-extended Quinone
- Effects of Donor Ion Doping on the Orientation and Ferroelectric Properties of Bismuth Titanate Thin Films
- Ferroelectric Properties of Nb-Doped Bi_4 Ti-3O_ Thin Films Prepared Using Surfactant in Acid or Basic Atmosphere
- Ferroelectric Properties of Tungsten-Substituted Bi_4Ti_3O_ Thin Film Prepared by Sol-Gel Method
- Vitiligo Skin Types in Koreans
- The changes of serum soluble intercellular adhesion molecule-1 after systemic steroid treatment in vitiligo
- B-5-17 LLR-based Ordering in Amplify-and-Forward Cooperative Spatial Multiplexing
- B-5-104 Cooperative Spatial Multiplexing : Decode and Transmit Scheme(B-5. 無線通信システムA(移動通信), 通信1)
- A Case of Erythromelalgia Successfully Controlled by Systemic Steroids and Pentazocine-Is It Related to a Unique Subtype of Neutrophilic Dermatosis?
- LARGE HYPERPLASTIC POLYP DEVELOPING AFTER ENDOSCOPIC MUCOSAL RESECTION OF GASTRIC ADENOMA IN A PATIENT RECEIVING IMMUNOSUPPRESSIVE THERAPY
- Regular Spectra and Universal Directionality of Emitted Radiation from a Quadrupolar Deformed Microcavity(General)
- What Determines the Direction of Far-Field Emission in Chaotic Microcavities?(Quantum Mechanics and Chaos)
- Ellipsometric Simulation and Preliminary Observation of East Crystallization Behavior of Ge_2Sb_2Te_5 Amorphous Thin Films at Elevated Temperature
- New Crystallization Kinetics of Phase Change of Ge_2Sb_2Te_5 at Moderately Elevated Temperature
- GAS HOLDUP AND VOLUMETRIC LIQUID-PHASE MASS TRANSFER COEFFICIENT IN A GEL-PARTICLE SUSPENDED BUBBLE COLUMN WITH DRAUGHT TUBE
- Topic Document Model Approach for Naive Bayes Text Classification(Natural Language Processing)
- Optical Properties of Polymer-like Organic Thin Films Deposited by Plasma-Enhanced Chemical Vapor Deposition Using Toluene as the Precursor
- Phylogenetic Analysis of the Small Hydrophobic (SH) Gene of Mumps Virus in Korea:Identification of a New Genotype
- Fast Fractal Image Coding Based on LMSE Analysis and Subblock Feature(Image Processing and Video Processing)
- Effects of SF_6 Addition to O_2 Plasma on Polyimide Etching
- Real-Time Growth Control of Ge-Sb-Te Multilayer Film as Optical Recording Media by In Situ Ellipsometry
- Irreversible Optical Properties of AgO_x Mask Layer with Temperature for Super-Resolution Near-Field Structure Application Investigated by in situ, ex situ Ellipsometry
- Study on the Properties of Interlayer Low Dielectric Polyimide during Cl-Based Plasma Etching of Aluminum
- Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
- Stochastic Analysis of Gas-Liquid-Solid Flow in Three-Phase Circulating Fluidized Beds
- Characterization of Pressure Signals in a Bubble Column by Wavelet Transform
- EFFECT OF SECONDARY AIR INJECTION ON BED-TO-WALL HEAT TRASFER IN A CIRCULATING FLUIDIZED BED
- Refinement of Low-Grade Clay by Microbial Removal of Sulfur and Iron Compounds Using Thiobacillus ferrooxidans
- EFFECT OF SECONDARY AIR INJECTION ON AXIAL SOLID HOLDUP DISTRIBUTION IN A CIRCULATING FLUIDIZED BED
- Acrodermatitis enteropathica with anorexia nervosa
- Investigation of Polyimide Thin Films Deposited by Ionized Cluster Beam
- BIOMECHANICAL ANALYSIS OF THE IMPLANT MALALIGHMENT IN POSTERIOR STABILIZED TOTAL KNEE REPALCEMENT (PS-TKR)(1B2 Orthopaedic & Rehabilitation Biomechanics II)
- Effects of Shear on Melt Exfoliation of Clay in Preparation of Nylon 6/Organoclay Nanocomposites
- Study of Oxygen-Doped GeSbTe Film and Its Effect as an Interface Layer on the Recording Properties in the Blue Wavelength
- Contralateral EEG Slowing and Amobarbital Distribution in Wada Test: An Intracarotid SPECT Study
- Partial Seizures Manifesting As Apnea Only in an Adult
- White-Matter Change in Mesial Temporal Sclerosis : Correlation of MRI with PET, Pathology, and Clinical Features
- Hypomethylation of the protein gene product 9.5 promoter region in gallbladder cancer and its relationship with clinicopathological features
- Second-Harmonic Generation of GaAlAs Diode Laser by Enhanced Doubling in LiIO_3 Crystal
- Thermal Reaction Characterization of an Epoxy Molding Compound
- Optimum Growth Conditions of Ge-Sb-Te Alloy Thin Film Investigated by Ellipsometry
- Spectro-Ellipsometry Investigation of Cascaded Crystallization Behavior of Phase-Change Ge-Sb-Te Alloy
- Altered Biochemical Properties of Transient Receptor Potential Vanilloid 6 Calcium Channel by Peptide Tags
- Spectro-ellipsometric Studies of Amorphization and Thermal Annealing in Ion-implanted Silicon
- Solids Behavior in Freeboard of FCC Regenerator
- Substrate Temperature Dependence of ZnO Films Prepared by Ultrasonic Spray Pyrolysis
- IS-28 Role of surgery in the management of Gestational trophoblastic neoplasia(Group4 Oncology4,International Session)
- Adaptive Feed-forward Automatic Gauge Control in Hot Strip Finishing Mill
- MOLECULAR CLONING AND EXPRESSION OF A CLOCK GENE (Per1) IN THE GOLDEN RABBITFISH, SIGANUS GUTTATUS(Physiology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Spinal Cord Infarction After Decompressive Laminectomy for Spontaneous Spinal Epidural Hematoma : Case Report
- Wastage of Water Wall Tubes in a Circulating Fluidized Bed Combustor with Two Gas Exits
- Growth of Silicon Nanocrystals by Low-Temperature Photo Chemical Vapor Deposition
- Temperature Fluctuations and Heat Transfer in Liquid Drop Columns
- Comprehensive geriatric assessment for community-dwelling elderly in Asia compared with those in Japan : II. Hongchon in Korea
- Image Coding Using Wavelet-Based Fractal Approximation
- Surface Treatment of Polymeric Fine Powders by CF_4 Plasma in a Circulating Fluidized Bed Reactor
- IS-3. Diffuse Microscopic Angiodysplasia with Nodular Lymphoid Hyperplasia Involving the Distal Ileum and Total Colon in an Infant : A Cause for Obscure Massive Lower Gastrointestinal Bleeding(International session)
- Oxygen Transfer in a Three-Phase Circulating Fluidized Bed with Viscous Liquid Medium
- IRRITATION AND BIOPHYSICAL PROPERTIES OF THE SKIN MEASURED BY NON-INVASIVE TECHNIQUES AFTER Q-SWITCHED ND-YAG LASER THERAPY IN PATIENTS WITH NEVUS OF OTA
- Melatonin reduces X-ray irradiation-induced oxidative damages in cultured human skin fibroblasts
- Block Loss Recovery Using Fractal Extrapolation for Fractal-Coded Images
- Increased Expression of Mucin 5AC mRNA and Decreased Expression of Epidermal Growth-Factor Receptor mRNA in Gallstone Patients
- Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells
- Hydrodynamic Properties in a Cold-Model Dual Fluidized-Bed Gasifier
- Detection of Enteroviruses and Mammalian Reoviruses in Korean Environmental Waters
- KINETICS OF NO_x REDUCTION BY UREA SOLUTION IN A PILOT SCALE REACTOR
- RADIAL SOLID MIXING CHARACTERISTICS IN SHALLOW GAS FLUIDIZED BEDS
- Complex Refractive Indices of GeSbTe-Alloy Thin Films : Effect of Nitrogen Doping and Wavelength Dependence
- Sputtering Pressure Effects on Magnetization Reversal Mechanism and Magnetic Switching Volumes of CoSmICr Films
- Optic Neuropathy and Central Retinal Vascular Obstruction as Initial Manifestations of Acute Retinal Necrosis
- Experimental Study of Vapor Deposition and Dew Points in Combustion Gases by Interferometric Technique
- Effect of Static Mixer Internals on Hydrodynamics and Axial Gas Mixing Characteristics in a Circulating Fluidized Bed
- Effect of tracer metabolism on PET measurement of [^C]pyrilamine binding to histamine H_1 receptors
- Drying Characteristics of Fine Powders in an Inert Medium Circulating Fluidized Bed
- Synthesis of Polyamide Dendrons Bearing Pyridine Groups as Multiple Hydrogen Bonding Parts on the Periphery
- Horizons, Thermofield Dynamics and Quantum Information(VIII Asia-Pacific International Conference on Gravitation and Astrophysics (ICGA8))
- Effect of Panax Ginseng Extract on the Development of Various Parasites
- Removal of Volatile Organic Compounds (VOCs) by Photocatalytic Reaction in a Circulating Fluidized Bed (CFB) Photoreactor
- Preparation and Characterization of TiO_2 Thin Films on Silica Gel Powders by Plasma Enhanced Chemical Vapor Deposition in a Circulating Fluidized Bed Reactor
- Ureteral nephrogenic adenoma in a renal allograft patient
- Do Escherichia coli extract and cranberry exert preventive effects on chronic bacterial prostatitis? Pilot study using an animal model