Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells
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概要
- 論文の詳細を見る
Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.
- 社団法人 日本農芸化学会の論文
- 2007-07-23
著者
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Kim Se-jae
Dep. Of Biology Jeju National Univ.
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Park Ji-gweon
Technology Innovation Center For Life Science Cheju National University
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CHOI Soo-Youn
Department of Life Science, Cheju National University
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KO Hee-Chul
Technology Innovation Center for Life Science, Cheju National University
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KANG Shin-Hae
Jeju Hi-Tech Industry Development Institute
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Ko Hee-chul
Technology Innovation Center For Life Science Cheju National University
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Lee Sun-Ryung
Department of Biology, Jeju National University
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Choi Soo-youn
Department Of Life Science Cheju National University
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Yoon Hoon-seok
Technology Innovation Center For Life Science Cheju National University
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KIM Jeong-Kook
Department of Life Sciences, School of Life Sciences and Biotechnology, Korea University
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KIM Se-Jae
Technology Innovation Center for Life Science, Cheju National University
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Kim Jeong-kook
Department Of Life Sciences School Of Life Sciences And Biotechnology Korea University
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Lee Sun-ryung
Department Of Life Science Cheju National University
関連論文
- Correlation between Flavonoid Content and the NO Production Inhibitory Activity of Peel Extracts from Various Citrus Fruits(Miscellaneous)
- Anti-neuroinflammatory Activity of Nobiletin on Suppression of Microglial Activation
- Involvement of Extracellular Signal-Regulated Kinase in Nobiletin-Induced Melanogenesis in Murine B16/F10 Melanoma Cells
- Sinensetin Attenuates LPS-Induced Inflammation by Regulating the Protein Level of IκB-α
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