Bovine viral diarrhea virus 2 Infection Activates the Unfolded Protein Response in MDBK Cells, Leading to Apoptosis
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概要
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Bovine viral diarrhea virus 2 (BVDV-2) strains are divided into cytopathic and non-cytopathic biotypes based on the ablity to induce cytopathic effects in cultured cells. The mechanism of cytopathogenicity of BVDV-2 is not well understood. We examined cytopathogenesis in MDBK cells resulting from BVDV-2 infections by microscopic examinations and microarray analysis. We found that BVDV-2 activates endoplasmic reticulum (ER) stress signaling pathways that contribute to apoptosis of infected cells. We also monitored the expression of ER stress marker gene by RT-PCR during BVDV-2 infection and demonstrated that infection of MDBK cells with a cytopathic strain of BVDV-2 induces glucose-regulated protein 78 expression. Infection with BVDV-2 also induces DNA-damage-inducible transcript 3 expression and downregulates the lectin-galactoside-binding soluble 1 level. These results show that cytopathic strains of BVDV-2 induce an ER stress response resulting in apoptosis.
著者
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FUJIHARA Masatoshi
Department of Veterinary Microbiology, School of Veterinary Medicine, Faculty of Agriculture, Iwate
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Harasawa Ryo
Department Of Veterinary Medicine Faculty Of Agriculture Iwate University
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Maeda Kouji
Department Of Cardiology Hiroshima General Hospital
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