The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity
スポンサーリンク
概要
- 論文の詳細を見る
We analyzed the effects of thiol compounds on the biological activities of 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC). Thiol compounds abolished the cytotoxic activity of 6-MITC, but did not abolish its activity augmenting cellular total glutathione levels and gamma-glutamylcysteine ligase gene expression. Thiol compounds might play an important role in the augmentation of several significant biological activities by overcoming the inherent limitations of 6-MITC.
- 社団法人 日本農芸化学会の論文
著者
-
Umetsu Hironori
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University
-
YAMAGUCHI Hideaki
Department of Material and Life Science, Graduate School of Engineering, Osaka University
-
Noshita Toshiro
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University
-
Kidachi Yumi
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University
-
Ryoyama Kazuo
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University
-
FUKE Yoko
Department of Food Science & Human Nutrition, Tokyo Metropolitan College
関連論文
- Isolation of Ursolic Acid from Apple Peels and Its Specific Efficacy as a Potent Antitumor Agent
- Effect of Phytosulfokine-α on Growth and Tropane Alkaloid Production in Atropa belladonna Hairy Roots
- Frequency of Mutations of the Transgene, which might Result in the Loss of the Glyphosate-Tolerant Phenotype, was Lowered in Roundup Ready^[○!R] Soybeans
- Direct Welding between Copper and Glass Substrates with Femtosecond Laser Pulses
- Cytotoxic Alkaloids of Pachysandra terminalis
- Anti-Tumor Activity of an Enzymatically Synthesized α-1, 6 Branched α-1, 4-Glucan, Glycogen
- Adxanthromycins A and B, New Inhibitors of ICAM-1/LFA-1 Mediated Cell Adhesion Molecule from Streptomyces sp. NA-148 : II. Physico-chemical Properties and Structure Elucidation
- Total Synthesis of Natural (+)-Phomopsolide B, an Antifeedant against Elm Bark Beetle
- Total Synthesis of Natural (+)-Phomopsolide B(Organic Chemistry)
- Characterization of (-)-Matairesinol as a Potent Inhibitor of Casein Kinase I in Vitro
- Effects of Cooking Methods of Cabbage on the Production of TNF-α and Induction of Quinone Reductase in Hepa 1c1c7 Cells
- Efficacy of a diazepam suppository at preventing febrile seizure recurrence during a single febrile illness
- Rat Small Intestine Muscle Relaxation Alkaloids from Orixa japonica Leaves
- 6-(Methylsulfinyl) hexyl Isothiocyanate Isolated from Wasabi (Wasabia japonica MATSUM) Suppresses Tumor Progression in an Experimental Mouse System
- Glycyrrhetinic Acid Induces Anoikis-Like Death and Cytoskeletal Disruption in the Central Nervous System Tumorigenic Cells
- The Augmenting Activity of 6-(Methylsulfinyl) hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity
- New Cytotoxic Phenolic Derivatives from Matured Fruits of Magnolia denudata
- The Augmenting Activity of 6-(Methylsulfinyl)hexyl Isothiocyanate on Cellular Glutathione Levels Is Less Sensitive to Thiol Compounds Than Its Cytotoxic Activity
- Machilin G and Four Neolignans from Young Fruits of Magnolia denudata Show Various Degrees of Inhibitory Activity on Nitric Oxide (NO) Production
- Detection of 6-(Methylsulfinyl)hexyl Isothiocyanate (6-MITC) and Its Conjugate with N-Acetyl-L-cysteine (NAC) by High Performance Liquid Chromatograpy-Atmospheric Pressure Chemical Ionization Mass Spectrometry (HPLC-MS/APCI)
- Differentiation of Serum-Free Mouse Embryo Cells into an Astrocytic Lineage is Associated with the Asymmetric Production of Early Neural, Neuronal and Glial Markers(Molecular and Cell Biology)
- Reinvestigation of Phenolic Ferrier Reaction : Selective Synthesis of Aryl O-Δ^2-Glycosides