Glycyrrhetinic Acid Induces Anoikis-Like Death and Cytoskeletal Disruption in the Central Nervous System Tumorigenic Cells

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概要

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• We analyzed the effects of glycyrrhetinic acid (GA), a licorice compound, on the induction of anoikis-like death and cytoskeletal disruption in the central nervous system (CNS) tumorigenic cells. GA was cytotoxic in time- and dose-dependent manners, and the tumorigenic cells shed floating cells upon the GA treatment and even some of the adherent cells were easily detached from the fibronectin-coated culture dish by gentle shaking and aspiration. Reculture of the detached cells revealed that the longer the duration of GA exposure, the less the number of the proliferatable cells. These results indicate that GA perturbs cell adhesion and induces anoikis-like cell death. Further, GA also induced morphologic changes and disturbed cytoskeletal proteins.

• 公益社団法人　日本薬学会の論文

著者

• YAMAGUCHI Hideaki

  Department of Material and Life Science, Graduate School of Engineering, Osaka University

• Noshita Toshiro

  Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University

• Kidachi Yumi

  Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University

• Umetsu Hironori

  Laboratory of Food Chemistry, Department of Life Sciences, Junior College, Gifu Shotoku Gakuen Unive

• Ryoyama Kazuo

  Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University

• Yamaguchi Hideaki

  Department Of Material And Life Science Graduate School Of Engineering Osaka University

• KAMIIE Katsuyoshi

  Department of Bioscience and Biotechnology, Faculty of Engineering, Aomori University

• Noshita Toshiro

  Department Of Bioscience And Biotechnology

• Kamiie Katsuyoshi

  Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Aomori University

• Yamaguchi Hideaki

  Department of Pharmacy, Faculty of Pharmacy, Meijo University

• Kidachi Yumi

  Department of Clinical Pharmacy, Aomori University

• Umetsu Hironori

  Laboratory of Food Chemistry, Department of Life Sciences, Junior College, Gifu Shotoku Gakuen University

• RYOYAMA Kazuo

  Department of Clinical Pharmacy, Aomori University

• Yamaguchi Hideaki

  Department of Industrial Chemistry, Faculty of Engineering, Miyazaki University

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