A Clinical Comparative Study of Piperacillin and Sulbactam/Ampicillin in Patients with Community-Acquired Bacterial Pneumonia
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概要
- 論文の詳細を見る
Objective To evaluate the clinical usefulness of piperacillin (4 g/day) therapy for community-acquired pneumonia compared to sulbactam/ampicillin (6 g/day). Methods A randomized prospective clinical study was conducted in patients with mild to severe community-acquired bacterial pneumonia. Results The overall clinical efficiency of piperacillin therapy (4 g/day) in these patients (41/53=77.4%) was comparable to that of sulbactam/ampicillin therapy (6 g/day: efficiency rate: 33/49=67.3%), when each therapy was administered intravenously for 3-7 days. With regards to clinical efficiency based on disease severity, bacteriological efficiency, improvement in chest X-ray findings and adverse reactions, the two therapies were comparable, even though we found more efficiency for patients who had underlying diseases and there were also cost benefits in piperacillin therapy, compared with sulbactam/ampicillin therapy Conclusion The results suggested that piperacillin therapy has good efficiency and tolerability and that it may be highly effective, even in cases of pneumonia with underlying diseases. This regimen may thus serve as a first line treatment of community-acquired pneumonia.
- 日本内科学会の論文
著者
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KOHNO Shigeru
Department of Internal Medicine, Nagasaki University School of Medicine
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IZUMIKAWA Koichi
Department of Laboratory Medichine, Nagasaki University School of Medicine
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Nakamura Shigeki
Department Of General Medicine Nagasaki University School Of Medicine
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Yamamoto Yoshihiro
Department Of Biological Science Graduate School Of Science Hiroshima University
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Kurihara Shintaro
The Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Imamura Yoshifumi
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedical Sciences
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Seki Masafumi
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedical Sciences
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Yanagihara Katsunori
Department Of Clinical Laboratory Nagasaki University Hospital
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Kakeya Hiroshi
Department Of Molecular Microbiology And Immunology Nagasaki University Graduate School Of Biomedical Sciences
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Tashiro Takayoshi
Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences
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Izumikawa Koichi
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
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Higashiyama Yasuhito
The Second Department of Internal Medicine, Nagasaki University School of Medicine
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Seki Masafumi
Department of Cardiology, Kitakyushu City Yahata Hospital
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Tashiro Takayoshi
Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences
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