Astemizole-Induced Torsades de Pointes in a Patient With Vasospastic Angina
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概要
- 論文の詳細を見る
Astemizole (Hismanal^(○!R)), an antihistamine agent, has been reported to be associated with ventricular arrhythmias. In this paper we present a case of QT prolongation and torsades de pointes (TdP) in a 77-year-old woman who had been taking astemizole (10 mg/day) for 6 months because of allergic skin disease. At the time of admission, the serum concentration of astcmizole and its metabolites was markedly elevated at 15.85 ng/ml, approximately 3 times the normal level. The patient was also taking cimetidine, a known inhibitor of cytochrome P-450 enzymatic activity, and during her admission was diagnosed as having vasospastic angina. To the best of our knowledge, this is the first report of astemizole-induced QT prolongation and TdP in Japan.
- 社団法人日本循環器学会の論文
- 1998-02-20
著者
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Shimokawa Isao
Nagasaki Univ. Nagasaki Jpn
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KOHNO Shigeru
Department of Internal Medicine, Nagasaki University School of Medicine
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Ikeda Satoshi
Department of Cardiovascular Medicine, Nagasaki University Graduate School of Biomedical Sciences
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Matsunaga Kazuo
Department of Hematology, Nagasaki Municipal Medical Center
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Oka Hiroyuki
Department Of Internal Medicine Karako Hospital
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Ogata H
Department Of Internal Medicine Karako Hospital
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Oka Hiroyuki
Department Of Applied Chemistry Faculty Of Engineering Osaka City University
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Miyahara Yoshiyuki
2nd Department Of Internal Medicine Nagasaki University School Of Medicine
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Asai Sadahiro
Department Of Internal Medicine Sasebo City General Hospital
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Matunaga Kazuo
Department of Internal Medicine, Sasebo City General Hospital
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Kubo Susumu
Department of Internal Medicine, Sasebo City General Hospital
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Miyahara Yoshiyuki
Department of Internal Medicine, Nagasaki University School of Medicine
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Osaka Atsumi
Kyoumachi Hospital
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Kubo Susumu
Department Of Internal Medicine Sasebo City General Hospital
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Ikeda Satoshi
Department Of Cardiovascular Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Matsunaga Kazuo
Department Of Hematology Nagasaki Municipal Medical Center
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Miyazaki Yoshitsugu
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Ohara Hiroshi
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyahara Yoshiyuki
Department Of Internal Medicine Nagasaki Memorial Hospital
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Miyahara Yoshiyuki
Department of Clinical Laboratory, Nagasaki University Hospital
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Ikeda Satoshi
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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