Adrenomedullin is not Related to Acute Hypoxic Pulmonary Vascular Response in Patients with Chronic Respiratory Disease
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概要
- 論文の詳細を見る
In the present study, acute hypoxia was induced in 19 patients with chronic respiratory disease to evaluate the corre lation between pulmonary circulation kinetics and adrenomedullin (AM) levels. Using radioimmunoassay (RIA), pulmonary circulation kinetics were evaluated before and after hypoxic loading (13% oxygen for 15 minutes) by determining AM levels in plasma obtained from the pulmonary artery (PA) and the right femoral artery (FA). There were no significant differences in pre-hypoxia plasma AM levels between samples obtained from the PA and FA, and plasma AM levels did not change after hypoxic loading. Subjects were classified into two groups [responders (R) and non-responders (NR) ] to evaluate changes in the mean pulmonary arterial pressure(笆ｳMPAP). There were no changes in AM levels between these two groups in either the PA or FA after hypoxic loading. These results suggest that AM do not appear to be related to hypoxic pulmonary vascular response to acute hypoxic loading in patients with chronic respiratory disease.
- 長崎大学の論文
著者
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Shimokawa Isao
Nagasaki Univ. Nagasaki Jpn
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Miyazaki Y
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Miyahara Yoshiyuki
2nd Department Of Internal Medicine Nagasaki University School Of Medicine
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FURUKAWA Katsuyuki
Second Department of Internal Medicine, Nagasaki University School of Medicine
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Iwasaki Tadasu
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Yakabe Kazuaki
Department Of Cardiology.nagasaki Municipal Medical Center
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Miyahara Yoshiyuki
Second Department Of Internal Medicine Nagasaki University School Of Mediciene
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Furukawa Katsuyuki
Second Department Of Internal Medicine Nagasaki University School Of Medicine
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Miyazaki Yoshitsugu
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Sciences
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