The first telithromycin-resistant Streptococcus pneumoniae isolate in Japan associated with erm(B) and mutations in 23S rRNA and riboprotein L4.
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概要
- 論文の詳細を見る
This report presents the case of a patient associated with a Streptococcus pneumoniae isolate that was resistant to a new ketolide antibiotic, telithromycin (minimum inhibitory concentration: 4 microg/ml). The patient, a 61-year-old female with bronchiectasis, was treated with 200-400 mg of clarithromycin daily for 6 years until the isolation of the resistant strain but without prior exposure to telithromycin. The strain was isolated from her sputum but not from the nasopharynx. This isolate carried erm(B) and had mutations in 23S rRNA and riboprotein L4. To our knowledge, this is the first case report concerning a telithromycin-resistant S. pneumoniae isolate in Japan by mutation in L4. Although the long-term clarithromycin administration may have contributed to the induction of resistance in this patient, this could not be confirmed, since S. pneumoniae was not isolated until the present episode.
- JJID Editorial Office National Institute of Infectious Diseasesの論文
著者
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Hirakata Yoichi
長崎大学 医学部第二内科学
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Miyazaki Yoshitsugu
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Miyazaki Yoshitsugu
長崎大学 第二内科
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Miyazaki Y
Dep. Of Lab. Medicine Nagasaki Univ. Graduate School Of Biomedical Sciences Nagasaki Univ. Hospital
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Hirakata Y
長崎大学 医学部第二内科学
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Higami Yoshikazu
Department Of Histology And Cell Biology Nagasaki University Graduate School Of Biomedical Sciences
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Miyazaki Yoshitsugu
Second Department Of Internal Medicine Nagasaki University Graduate School Of Biomedical Science
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Hirakata Yoichi
Department Of Clinical Laboratory Medicine Nagasaki University School Of Medicine
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Wada Akihito
National Inst. Of Infectious Diseases Tokyo Jpn
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Harada Yousuke
Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Miyazaki Yoshitsugu
Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences Nagasak
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Hara Yukiko
Department Of Laboratory Medicine Nagasaki University Graduate School Of Biomedical Sciences
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Hirakata Yoichi
Department Of Clinical Microbiology And Management And Analysis Of Infectious Diseases Tohoku University Graduate School Of Medicine
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