Gefitinib Improves Bronchorrhea from Mucinous Bronchioloalveolar Carcinoma and Serum Surfactant Protein-D Levels is a Novel Surrogate Predictor of Treatment Benefit
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概要
- 論文の詳細を見る
Background. Mucinous bronchioloalveolar carcinoma (BAC) with goblet cell features causes bronchorrhea and pneumonia-like consolidation, and does not produce surfactant protein (SP). This subtype of lung cancer is known to harbor K-ras mutations, resulting in resistance to treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor gefitinib. Case. However, we report a case in which gefitinib improved bronchorrhea from mucinous BAC with high serum SP-D levels. The tumor cells had an EGFR mutation, and did not show the features of goblet cells. Conclusion. Mucinous BAC is heterogeneous, and high serum SP-D levels may be a useful marker of treatment benefit with gefitinib.
- 日本呼吸器内視鏡学会の論文
- 2013-03-25
著者
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KOHNO Shigeru
Department of Internal Medicine, Nagasaki University School of Medicine
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Iwasaki Keisuke
Division Of Surgical Oncology Department Of Surgery Nagasaki University Graduate School Of Biomedica
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Soda Hiroshi
Division of Clinical Infectious Diseases, Department of Internal Medicine, School of Medicine, Showa University
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Fukuda Yuichi
Division of Respiratory Medicine, Sasebo City General Hospital
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Kitazaki Takeshi
Division of Respiratory Medicine, Sasebo City General Hospital
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Adachi Misato
Division of Respiratory Medicine, Senju Hospital
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Iwanaga Naoki
Department of Second Internal Medicine, Nagasaki University School of Medicine
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Soda Hiroshi
Division of Respiratory Medicine, Sasebo City General Hospital
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Kohno Shigeru
Department of Second Internal Medicine, Nagasaki University School of Medicine
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Iwasaki Keisuke
Division of Pathology, Sasebo City General Hospital
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