Botulinum Toxin Type A for Migraine Prophylaxis in the Japanese Population: An Open-Label Prospective Trial
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概要
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Objective To evaluate the efficacy and tolerability of Botulinum Toxin Type A (BoNT-A) for migraine prophylaxis. Methods Nineteen Japanese adult patients (50 ± 10 years old), who met the International Classification of Headache Disorders 2nd Edition (ICHD II) criteria for migraine and had five or more migraine attacks a month, were enrolled in this open-label prospective study. A total of 50 units of BoNT-A were injected in 19-fixed sites of the muscles including procerus, corrugator, frontalis, temporalis and occipitalis. All participants were advised to stop taking preventive medicine from one month before and three months after BoNT-A injection. Migraine disability assessment (MIDAS), migraine questionnaire and headache diary were used for the evaluation of efficacy. Seven patients received repeated injection combined with prophylactic medication. Result We excluded five patients from the analysis because four patients had medication overuse headache and one continued preventive medicine. Mean MIDAS score decreased significantly two months after the injection. Thirteen of 14 patients stated subjective improvement after the injection on the migraine questionnaire. The amount of analgesics consumption or headache frequency did not change after injection, but the frequency of severe migraine attacks decreased significantly. No serious adverse event was reported. Repeated injections also showed significant reduction in MIDAS score three months after the second and third injections. Conclusion BoNT-A injection was an effective and safe treatment for migraine prophylaxis among the Japanese population. A randomized placebo control trial is necessary to confirm its efficacy.
- 社団法人 日本内科学会の論文
著者
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Iizuka Takahiro
Department Of Medicine (neurology) Kitasato University School Of Medicine
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Suzuki Kosuke
Department Of Applied Chemistry Graduate School Of Engineering The University Of Tokyo
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SAKAI FUMIHIKO
Department of Internal Medicine, School of Medicine, Kitasato University
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Suzuki Kosuke
Department of Neurology, School of Medicine, Kitasato University
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Iizuka Takahiro
Department of Neurology, School of Medicine, Kitasato University
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